Evaluation of Hepatoprotective and Antioxidant Effect of Solanum Seaforthianum Leaf Extract against Ccl4 - Induced Li~1

Pugazhendhi, S (2017) Evaluation of Hepatoprotective and Antioxidant Effect of Solanum Seaforthianum Leaf Extract against Ccl4 - Induced Li~1. Masters thesis, Annai J.K.K. Sampoorani Ammal College of Pharmacy, Komarapalayam.


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INTRODUCTION: LIVER-INTRODUCTION:The liver has pivotal rule in human metabolism, including detoxification, protein synthesis, and the production of bio-chemicals necessary for digestion. The liver is necessary for survival; there is no currently way to compensate for the absence of liver function long term, however liver cell can regenerate. It produces and secretes bile that stored in gallbladder which used to break down and digest fatty acids in food. 1. It also produces prothrombin and fibrinogen, both are blood-clotting factors. 2. It converts sugar into glycogen, which it stores until the muscle cells need energy and it is secreted into the blood stream as glucose. 3. It synthesizes protein and cholesterol and convert carbohydrates and protein into fats, which is stored for later uses. 4. It also produces blood protein and enzymes needed for digestion and other bodily functions in body. 5. The liver stores critical trace elements such as iron, copper, as well as vitamins A, D, and B12. 6. The liver is responsible for detoxifying of poisonous substances in the body. AIM OF PRESENT STUDY:In recent year there has been a tremendous increase in demand for herbal drugs due to its safety, efficacy and better therapeutic results and also due to its economic pricing as compared to synthetic or allopathic drugs, which have several therapeutic complications. Looking to the scope of herbal drugs and increasing its demand especially in disease of liver, hypertension, diabetes, cancer, arthritis and skin disease etc, it was planned to study Solanum seaforthianum in detail due its effectiveness for liver problems, especially for jaundice. Solanum seaforthianum, selected for study was made on the basis of its, a) Easy availability b) Folklore claiming its therapeutic use as liver protection and for jaundice. c) Degree of research work which is not done. Very less pharmacological studies have been carried out on the Solanum seaforthianum. Hence, we have decided to submit the project on Solanum seaforthianum which includes detailed Pharmacognostical, Preliminary Phytochemical and Pharmacological (Acute oral toxicity study, Hepatoprotective activity with antioxidant effect) studies to provide scientific validation to its folklore claims. SUMMARY AND CONCLUSION: The present study was undertaken to determine the hepatoprotective and antioxidant effect of methanolic extract from leaf of Solanum seaforthianum The Pharmacognostical studies made on the powdered leaves of Solanum seaforthianum like ash values, extractive value, loss on drying gave valuable information. This will help for correct identification of the plant. The preliminary phytochemical investigation showed the presence of, alkaloids, glycosides, flavonoids, and steroids, carbohydrate, fatty acids and proteins and phenolic compounds.in methanol extract. Histopathological studies on isolated liver revealed that methanolic extract of Solanum seaforthianum reversed the liver damage caused by CCl4. The normal pattern of histology of liver was observed. Phytochemical screening revealed the presence of flavonoids. Flavonoids have been documented to possess potent antioxidant and free radical scavenging effect. Example; Solanum seaforthianum contain 2-di-Cglcosylflavones of vicenin and lucenin type, anthocyanin-cynidin-3- glucoside,luteolin-7-glycoside and mono-C-glcosyl flavones – vitexin and orientin Based on the results obtained from the present study, it can be concluded methanolic extract of Solanum seaforthianum is found to be more potent and effective hepatoprotective and antioxidant activity.

Item Type: Thesis (Masters)
Additional Information: Reg. No.261525710
Uncontrolled Keywords: Hepatoprotective ; Antioxidant Effect ; Solanum ; Seaforthianum Leaf Extract ; Ccl4 - Induced Li~1
Subjects: PHARMACY > Pharmacology
Depositing User: Ravindran C
Date Deposited: 21 Mar 2018 08:11
Last Modified: 21 Mar 2018 08:11
URI: http://repository-tnmgrmu.ac.in/id/eprint/6414

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