A Study of Prevalence of Diastolic Dysfunction in Rheumatoid Arthritis Patients

Ramya, J (2012) A Study of Prevalence of Diastolic Dysfunction in Rheumatoid Arthritis Patients. Masters thesis, Madurai Medical College, Madurai.


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AIMS: The aim of this study was to evaluate the prevalence of diastolic dysfunction in rheumatoid arthritis patients and to compare them with age and sex matched controls. The correlation between diastolic dysfunction and disease activity was looked for. METHODS: The study was a cross sectional study involving 40 patients (8 maleand 32 female) with RA without clinically evident heart disease and 20 healthy subjects (16 female and 4 male) who served as a control group. Both groups were matched for age and sex. Echocardiographic and Doppler studies were conducted in all patients with RA and control subjects. RESULTS: Our study shows that patients with RA have a higher prevalence of diastolic dysfunction (40%) than non-RA subjects (10%). The ejection fraction was preserved in all patients. The result in this study showed E/A ratio in RA patients was 1.135 (0.822–1.448) and in the control group was 1.305 (1.122–1.487). Dt in RA patients was longer compared to the control population (180 ms ± 27..77vs. 160.5 ms ± 11.95) with a significant p value.). The E/E′ index of RA patients was 8.447 ± 2.32 which was higher compared to the study population 7.946+/- 0.43. The LA volume indexed to body surface area was significantly higher in patients of RA compared to study group. It was 23.03+/- 7.53 in study group as compared to 18.18+/- 2.44 with a significant p value of 0.007. This study showed significant correlations between duration of disease, disease severity and echocardiographic measurements. There were no statistically significant differences between diastolic dysfunction and normal diastolic function groups in term of age of the patient, duration of disease, DAS 28, rheumatoid factor. CONCLUSION: Prevalence of diastolic dysfunction in the rheumatoid arthritis group (40%) was higher compared to controls (10%). LV diastolic function had significant correlation with RA disease severity and duration of disease.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Prevalence ; Diastolic Dysfunction ; Rheumatoid Arthritis Patients.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 20 Mar 2018 02:48
Last Modified: 20 Mar 2018 02:48
URI: http://repository-tnmgrmu.ac.in/id/eprint/6376

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