Neelakandan, M (2016) Detection and Quantification of Phthalates in Liquid Food Products by GC-MS. Masters thesis, College of Pharmacy Madras Medical College, Chennai.
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Abstract
INTRODUCTION: Packaging is the process by which the products are suitably placed so that they should retain their therapeutic effectiveness from the time of their packaging till they are consumed. “ Packaging may be defined as the art and science which involves preparing the articles for transport, storage, display and use”. A package is a manufactured product consisting of any material or material combination used to present, contain, protect, handle and distribute goods, from raw materials to finished products, in every phase of the distribution chain. Thus the basic packaging functions follow: 1. To contain the product, 2. To present and identify the product, 3. To protect the products physical integrity, 4. To preserve the products properties and quality characteristics, 5. To prepare the product for handling during transportation and commercial distribution, 6. To inform the consumer. Packages have changed with time in response to the following social factors: population growth, urbanization, necessity to avoid food detoriation and loss, internationalization of commerce, greater awareness about hygiene, consumption of more natural foods and environmental detoriation. AIM AND OBJECTIVE: Analytical instrumentation plays an important role in production and evaluation of new product. Analytical technique is a method that is used to determine the concentration of a chemical compound or chemical element. There are a wide variety of techniques used for analysis, from simple weighing to titration to advanced techniques using highly specialized instruments. Analytical techniques play a crucial role in new drug development. An appropriate analytical method is required to study the pharmacokinetic, therapeutic and toxicological effects of new drug entities. The present work is focused on developing new analytical technique for determination and quantification of phthalates contamination in liquid food products. In the present scenario, the market is flaked with consumables containing phthalates induced food samples and consumers are taken to ride. No studies have been carried out for determination of phthalates in food products in INDIA. The world we live in today is directly influenced by the progression of science. From ancient to modern times, the role of science has always been to further the development of society. This project addresses aspects concerning the well-being of the individuals and families in the society. SUMMARY AND CONCLUSION:The present work deals with the development and validation of GC-MS technique for the detection and quantification of phthalates. The validation of the proposed method was carried out as per ICH guidelines. Linearity was obeyed in the concentration range of 0.5 to 5 mg/L. The developed method was successfully applied to the analysis of phthalate esters in liquid food samples. The sample preparation method for liquid samples was quick and easy to accomplish using n-hexane as extraction solvent which provided constant and high recoveries even at trace level. The average recovery of the sample analysis by this method was 102.1%. Among the phthalates generally present, Di 2-ethyl hexyl phthalate was detected in all the samples in the concentration range of 1.31 to 1.65 mg/L. The GC-MS measurement method is highly accurate as demonstrated with precise calibrations and spiked liquid samples. The proposed GC-MS method has good usability, provides the necessary sensitivity and delivers the complete spectrum information for identification and confirmation of a wide variety of possible phthalate ester contaminations by comparison with the NIST mass spectral library. The determination of phthalate plasticizers using the proposed GC-MS method is very sensitive and accurate. It is easy to perform, rapid and covers a wide linear range to meet the need for trace level detections of PAEs in liquid food samples. The advancement of medical science always has influenced mankind. Science builds on itself over time, each period gives its own contribution. Sometimes the knowledge is not true, but it is in the act of trying that leads to success. This accumulation of medical knowledge over time has allowed society to advance health care to where it is today. In conclusion, the sciences emerged from human curiosity and ingenuity because of the questions and problems the environment has thrust upon us. The information gained is not always equitable but does serve as a medium for correct sciences to appear. Thus, if history repeats itself, the road ahead for science will be intermittently rewritten to serve the future needs of both scientific communities and society at large. This project can be considered as the effect of an activity on the social fabric of the community and well-being of the individuals, thus imparting a social impact in the society.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No. 261415714 |
| Uncontrolled Keywords: | Detection ; Quantification ; Phthalates ; Liquid Food Products ; GC-MS. |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 19 Mar 2018 08:38 |
| Last Modified: | 21 Mar 2018 08:11 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6344 |
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