Arunpandiyan, J (2017) Extraction, Phytochemical Investigation and Biological Evaluation of Bark of Syzygium Cumini (L.). Masters thesis, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil.
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Abstract
INTRODUCTION:The study of medicinal plants is neglected by medical men all over the world, but more so in India. It is our misfortune that the chemistry and pharmacology of most of these plants have not been properly investigated. The ease and cheapness with which these are procurable the marvelous powers that are attributed to them in the cure of different diseases encourages us to investigate their properties and prove their pharmacological actions. The Syzygium cumini (L.) Skeels (Syns. Syzygium jambolana DC, Eugenia cumini Druce, Eugenia jambolana Lam.),commonly known as Jamun, belongs to the family Myrtaceae or Myrtle1. The other common names of jamun are Indian blackberry, Java plum, Jambu, black plum and Jambul etc2. S. cumini is an emerging fruit crop of the twenty-first century. The jamun fruit have high medicinal value as well as different plant parts possess varied uses to mankind.In the production of jamun, India get second place in all over the world. Uttar Pradesh state is the largest producer followed by Maharashtra, Tamil Nadu, Gujarat, Assam. Ripe fruits are purpulish with high content of anthocyanin with a pleasant odour,astringent taste and are processed to make vinegar, jam, jellies and squash. It gives authority of due to the presence of the various phytochemical constituents such as alkaloids, fatty acids, steroids and tannins. It is multipurpose tree cultivating for varied uses as a road bordered by trees for wind break, preserving fishing nets and tanning leather by brown dye which obtained from bark due to its have high value of tannin content. The wood also used for building, carpentry, fuel wood and preparation of different agricultural implements.AIM AND OBJECTIVES:Herbal research is still a vital source of novel pharmaceutical products moreover it is one of the best reservoirs for synthesis of novel structural based bioactive compounds. Near to 30% of the current using drugs comes from natural products and an additional 20% are structural alteration of the lead compounds from natural source. It is estimated that only 15% of higher plants have been investigated for potentially useful biological activity. In spite of the presence of known antioxidant medicine in the pharmaceutical market, remedies from medicinal plants are used with success to treat this disease. Several traditional plant treatments like diabetes cardiac complicated disease, malaria, antiinsecticide etc. are used throughout the world. Herbal drugs and formulations are frequently considered to be less toxic and free from side effects than synthetic one. Hence, in modern days, huge attention has been directed towards recognition of plants with antidiabetic, cardiac complicated disease, malaria, antiinsecticide etc, ability that may be used effectively for human consumption. There has been rapid expansion of different classes of antioxidant drugs with distinctive pharmacological mechanism of action and, also, they have various toxicological profiles. The literature review revealed that the extraction process with various solvents based on polarity with bark of syzygium cuimini has not been experimentally studied, as well as no detailed study has been carried out on the antioxidant as well as antimicrobial activity. From the literature survey it has been found that the barks of the selected plant (syzygium cuimini) are being used traditionally in the treatment of diabetes, based upon their traditional and ethnopharmacological information’s. The objective of the present research work focused on the investigation of phytochemical constituents of their various extractions based on their polarity and study of in vitro antioxidant as well as in vitro antimicrobial activity.PLAN OF RESEARCH WORK The following schedule of the research work has been planned and performed. 1. Selection of plants based upon literature survey and traditional claim. 2. Identification, authentication of plant(s) and collection of barks of the plant. 3. Preparation of extracts of various solvents based on polarity. 4. Investigation of preliminary phytochemical studies. 5. IN VITRO STUDIES FOR VARIOUS EXTRACTS.SUMMARY:Herbal research is still a vital source of novel pharmaceutical products moreover it is one of the best reservoirs for synthesis of novel structural based bioactive compounds. Near to 30% of the current using drugs comes from natural products and an additional 20% are structural alteration of the lead compounds from natural source. It is estimated that only 15% of higher plants have been investigated for potentially useful biological activity. In spite of the presence of known antioxidant medicine in the pharmaceutical market, remedies from medicinal plants are used with success to treat this disease. Several traditional plant treatments like diabetes cardiac complicated disease, malaria, antiinsecticide etc. are used throughout the world. Herbal drugs and formulations are frequently considered to be less toxic and free from side effects than synthetic one. Hence, in modern days, huge attention has been directed towards recognition of plants with antidiabetic, cardiac complicated disease, malaria, antiinsecticide etc, ability that may be used effectively for human consumption. There has been rapid expansion of different classes of antioxidant drugs with distinctive pharmacological mechanism of action and, also, they have various toxicological profiles. From the literature survey it has been found that the barks of the selected plant (syzygium cuimini (L.).) are being used traditionally in the treatment of diabetes, based upon their traditional and ethnopharmacological information’s The objective of the present research work focused on the investigation of phytochemical constituents of their various extractions based on their polarity and study of in vitro antioxidant as well as in vitro antimicrobial activity. The barks of Syzygium Cumini (L.). were collected from plants growing in the Krishnan koil, virudhunagar district during the months of July–August, 2016. It was then authenticated by Dr. Stephan, Dept. of Botany, The American College, Madurai.The bark was dried at 400 C for 15 days, then it was blended into coarse powder by electrical grinder. The powdered drug was passed through sieve No.22 to get uniform particle size. The barks (1000gm) were extracted by macerating with 2.5 litter of Petroleum ether for 7 days at room temperature in a dark cabinet. After 7 days, the extracts were collected by filtration, the marc was separated.Solvent extract was evaporated to dryness using rotary evaporator and weighed.CONCLUSION:In conclusion, the present study provides evidence that barks of Syzygium Cumini (L.). extracts shows significant antimicrobial as well as potential free radical scavenging activity. These In vitro assays demonstrate that bark extracts of Syzygium Cumini (L.). are important sources of natural antioxidants, which might be useful as preventive agents against oxidative stress and hence currently the evaluation of In vivo antioxidant activity of these extracts are in progress.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg No: 261515351 |
| Uncontrolled Keywords: | Phytochemical Investigation ;Biological Evaluation; Syzygium Cumini (L.) |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 16 Mar 2018 09:23 |
| Last Modified: | 16 Mar 2018 09:23 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6319 |
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