Phytochemical and Pharmacological Evaluation of Pedalium Murex Linn Leaves

Vinitha, A (2017) Phytochemical and Pharmacological Evaluation of Pedalium Murex Linn Leaves. Masters thesis, J. K. K. Nattraja College of Pharmacy, Komarapalayam.


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INTRODUCTION:Ayurveda was derived from the two Sanskrit words - Ayus, or “life” and Veda, or “knowledge”. Ayurveda has been translated as “the knowledge of life” and as “the science of life”. It has been suggested but one modern writer that a more appropriate translation would be “the knowledge of life span”.4 Plants, especially used in Ayurveda can provide biologically active molecules and lead structures for the development of modified derivatives with enhanced activity and / or reduced toxicity. The small fraction of flowering plants that have so far been investigated have yielded about 120 therapeutic agents of known structure from about 90 species of plants. Some of the useful plant drugs include vinblastine, vincristine, taxol, podophyllotoxin, camptothecin, digitoxigenin, gitoxigenin, degoxigenin, tubocurarine, morphine, codeine, aspirin, atropine, pilocarpine, capscicine, allicin, curcumin, among others.AIM AND PLAN OF WORK:As know that everything in this world change time by time, since thousands of year the era was of ayurveda or herbal origin drug. But last few years it was replaced by allopathic system of medicine, which was fastly accepted worldwide, but latter due to its lot of adverse effect, again men step down on Ayurveda because of its better therapeutic result and safety profile and now the people are more believing in natural origin drug. Countless drugs have entered in the International Pharmacopoeia through the study of Ethno pharmacology and traditional medicines. For ayurveda and other traditional medicines newer guidelines of standardization, manufacture and quality control are required. Employing a unique holistic approach, ayurvedic medicines are usually customized to an individual constitution, Traditional knowledge, driven drug development can follow a reverse pharmacology path and reduce time and cost of development. Powerful search engine and most importantly, will greatly facilitate international, focused and safe natural product research to rediscover the drug discovery process. Looking to the scope of herbal drug and increasing demand especially in case of diseases like liver disorders, hypertension, diabetes, cancer, diarrhoea, arthritis and skin diseases etc. Hence, it is planned to study a plant like Pedalium murex Linn which is having a variety of traditional uses. This plant is selected for present study based on its easy availability, degree of research work which is not done. The literature survey revealed that some amount of pharmacological work has been carried out on Pedalium murex Linn. Many works had been done previously in the flowers and seeds of Pedalium murex Linn. But the leaves of the plant are also having many traditional uses. So in order to explore the activities in the leaves of Pedalium murex Linn. I planned to go for the following studies.SUMMARY:In the thesis entitled Phytochemical and Pharmacological Evaluation of Pedalium murex Linn Leaves (Family: Pedaliaceae) has been studied to compare four different extracts such as n-hexane, chloroform, ethyl acetate and ethanol (90% v/v) and given the detailed report on phytochemical and pharmacological studies. The leaves of Pedalium murex Linn were selected for present project on the basis of ethanobotanical information. Literature survey revealed that not much work has done in this plant. So I felt it worthwhile to validate scientifically, the folkclaim for its therapeutic activity. The detailed preliminary phytochemical investigations proved its appropriate identification and rationalized its use as a drug of therapeutic importance. This plant have so many phytoconstituents like flavonoids, alkaloids, saponins, tannins and so on. The phytoconstituents are found to possess many pharmacological activities like antioxidant, anticancer, antiinflammatory, antimicrobial activities. So it was planned to isolate active constituents from ethanol extract of Pedalium murex Linn leaves.CONCLUSION:The present study concluded that the phytoconstituents were isolated from the leaves of ethanol extract of Pedalium murex Linn and characterized systematically with IR, H1 NMR and Mass spectroscopy. The spectral datas of the isolated compounds suggested that EEPM 1 showed the structural similarities with Stigmast-5-en-3 beta-ol and EEPM 2 may be (10α)-2β, 3α, 16α, 20, 25- Pentahydroxy-9β-methyl-19-norlanost-5-ene-11, 22-dione. All the four extracts were screened for MCF-7 and HeLa cell lines by MTT assay method. In both the cell lines, ethanol extract produced more significant in vitro anticancer activity than other extracts. It showed that triterpenoids and steroids were present in extract might be responsible for the anticancer activities.

Item Type: Thesis (Masters)
Additional Information: Reg.No.261515204
Uncontrolled Keywords: Phytochemical ; Pharmacological ;Pedalium Murex Linn Leaves
Subjects: PHARMACY > Pharmaceutical Chemistry
Depositing User: Ravindran C
Date Deposited: 16 Mar 2018 09:14
Last Modified: 16 Mar 2018 09:14

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