A Study on the Correlation of Serum Uric Acid and Microalbuminuria in Prehypertension

Vaishnavi, S (2011) A Study on the Correlation of Serum Uric Acid and Microalbuminuria in Prehypertension. Masters thesis, Madurai Medical College, Madurai.


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AIMS AND OBJECTIVES: 1. To study the prevalence of hyperuricaemia in prehypertensive individuals. 2. To study the relationship between uric acid and microalbuminuria in prehypertensive adults. 3. To study if hyperuricemia has an independent role in target organ damage among prehypertensive subjects, as reflected by microalbuminuria. MATERIALS AND METHODS: SETTING: Outpatient clinic of Government Rajaji Hospital, Madurai DESIGN OF STUDY: Analytical-cross sectional study. PERIOD OF STUDY: Six months (March 2010-October 2010). SAMPLE SIZE AND SELECTION OF STUDY SUBJECTS: Hundred prehypertensive subjects(both newly and previously diagnosed) attending the outpatient clinic were included in this Analytical cross sectional study. This study group included males and females in the age group of 20-45years. SUMMARY: This study “CORRELATION BETWEEN SERUM URIC ACID AND MICROALBUMINURIA IN PREHYPERTENSION” was carried out in Govt. Rajaji Hospital, Madurai Medical College, Madurai from March 2010 to October 2010. 100 cases of prehypertension in the age group of 20-45years were studied during this period.Male subjects-43% and females-57%. Hyperuricaemia was found to be strongly associated with microalbuminuria in prehypertensive subjects. Increased uric acid level in a prehypertensive group should be considered as a risk factor for cardiovascular disease. CONCLUSION: The following conclusions were derived from the study, 1.Prehypertension clusters with other cardiovascular risk factors like smoking, alchoholism, dyslipidemia ,microalbuminuria and hyperuricaemia. 2.Hyperuricaemia is an independent risk factor for microalbuminuria and thereby cardiovascular risk in prehypertension. 3. Urinary albumin excretion rate can be used as an immediate end point to evaluate the outcome of lowering the uric acid level in future investigations, and this will help draw a conclusion regarding its relation with cardiovascular disease. 4. As per JNC 7, pharmacological treatment is recommended for prehypertension, only if associated with diabetes, chronic kidney disease,microalbuminuria, etc, this study suggests that the subset of patients with hyperuricaemia can also be regarded as a high risk group who could benefit from blood pressure lowering therapy.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Serum Uric Acid ; Microalbuminuria ; Correlation.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 16 Mar 2018 04:26
Last Modified: 15 Jun 2018 02:51
URI: http://repository-tnmgrmu.ac.in/id/eprint/6306

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