Abdulkadar, M (2012) Formaldehyde Cross Linked Hydrogel Beads a New Matrix for Sustained Release of Dexibuprofen. Masters thesis, Periyar College of Pharmaceutical Sciences for Girls, Tiruchirappalli.
|
Text
ABDULKADAR M.pdf Download (3MB) | Preview |
Abstract
Oral drug release system is the most popular route, which is due in part to the ease of administration and to the fact that gastrointestinal physiology offers more flexibility in dosage form design than most other routes. With the concomitant recognition of the therapeutic advantages, greater attention has been focused on the development of controlled or extended release drug delivery systems. The first sustained release tablets were made by Howard Press in New Jersey in the early 1950's. Based on the literature survey, dexibuprofen was selected for the research work. The results herein presented indicate that a new dexibuprofen-loaded crosslinked hydrogel beads [SAC1.5] were obtained with high encapsulation efficiency and good sustained release over 12 hours presenting promising characteristics as compared to conventional calcium alginate beads from previous studies. The use of polymer combination successfully delays dexibuprofen release, which can be tailored to produce a suitable single dose administration per day. Physicochemical characterization demonstrates the formation of a new hydrogel matrix shows that dexibuprofen does not interfere with the new matrix hydrogel formation process. Therefore, matrix modification by an appropriate method, such as suitable cross-linking reaction, is crucial in the controlled release of dexibuprofen from hydrogel beads. The formulation SAC1.5 has achieved the objective of sustained crosslinked hydrogel beads. The ionotropic gelation method for the preparation of these cross-linked hydrogel beads containing dexibuprofen system for oral delivery was found to be simple, reproducible, easily controllable, economical and consistent process.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Formaldehyde ; Cross Linked Hydrogel Beads ; New Matrix ; Sustained Release ; Dexibuprofen. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 29 Jun 2017 07:25 |
| Last Modified: | 10 Dec 2017 03:24 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/629 |
Actions (login required)
 |
View Item |
