Vijay Babu, C (2008) Haematological Profile of Pulmonary Tuberculosis Patients With and Without HIV. Masters thesis, Madurai Medical College, Madurai.
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Abstract
The study “HAEMATOLOGICAL PROFILE OF PULMONARY TUBERCULOSIS PATIENTS WITH AND WITHOUT HIV” was done in 60 patients, with 30 patients in TB with HIV and 30 patients in TB without HIV, who attended the department of thoracic medicine and anti retroviral therapy centre, GRH, Madurai. Pulmonary tuberculosis patients were detected by clinical examination and by sputum positivity for AFB, using Ziehl-Nielson technique. Among pulmonary tuberculosis patients, HIV was confirmed by both ELISA and WESTERN BLOT assay. After a baseline investigations, complete haemogram was done on these patients using automated analyzer and peripheral smear examination. In our study, 83.3% were males and 16.6 % were females in the TB with HIV group. Whereas 76.6% were males and 23.3% were females in the TB without HIV group. Hence males dominated in both groups. In our study, 70% of patients were in the age group of 25 – 45 years in the TB with HIV group, whereas 86.6% 0f patients were in age group of 25 – 45 years in the TB without HIV. Hence, both the disease predominantly affect adults. In our study, 90 % of patients were underweight with BMI less than 18.5, in TB with HIV group, and 73.3% of patients were underweight in TB without HIV group. Since both disease causes chronic wasting, co-infection of TB with HIV may have deleterious effect in BMI. In our study, 80 % were anemic in the TB with HIV and 66.6% were anemic in TB without HIV group. Among those anemic patients, male patients were more (70% vs 34%) anemic. In our study, WBC count was not much altered in both the study groups, in which more than 65% of patients had normal WBC count in the TB with HIV groups and 70% of patients had normal WBC counts in TB without HIV. Since HIV was in early stages, the WBC count has not drastically reduced. In our study, 63.3% of patients with TB and HIV had thrombocytopenia, whereas only 10% of patients had thrombocytopenia in TB without HIV group. Instead, 36.6% of patients had thrombocytosis in the TB without HIV group. Since isolated thrombocytopenia is a well documented feature in HIV patients, and either normal platelet counts or thrombopoeisis occur in pulmonary tuberculosis patient per se, the co-infection TB and HIV has drastically reduced the platelet count in these patients. In our study, yet another finding is that, patients with tuberculosis per se have increased ESR count, whereas TB-HIV coinfection has drastically reduced the ESR count. Among patients with TB and HIV 83.3% of patients had ESR less than 60 mm/hr., whereas 96.6% of TB without HIV patients had ESR greater than 60 mm/hr. since, ESR is a marker of chronic inflammatory states like TB and HIV is a immunosuppressive state, the co-infection of TB with HIV has drastically reduced ESR values in these patients.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Haematological Profile ; Pulmonary Tuberculosis Patients ; With and Without HIV. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 15 Mar 2018 08:06 |
| Last Modified: | 15 Mar 2018 08:06 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6255 |
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