Vidya, S (2006) Blood Lead Levels in Primary Hypertension. Masters thesis, Madurai Medical College, Madurai.
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Abstract
Blood lead level strongly correlates with hypertension. The present study was aimed to study the blood lead level in patients with primary hypertension and to find out its association with sex, smoking status and target organ damage. With rigid criteria 30 patients were selected and evaluated on social, clinical and laboratory aspects after institutional ethical clearance with an informed consent. The data were entered in computer and analyzed statistically. The controls were matched for age and sex compared to cases. There were 19 males and 11 females in the case group and 18 and 12 respectively in control group. The mean systolic BP was 166.66 mmHg and 105.33mmHg diastolic. The mean lead levels were significantly higher in hypertensives (Mean 25.34 ±7.59 μg/dL) compared to controls (7.36±3.62 μg/dL). The percentage of persons with blood lead levels > 10 μg/dL is also greater in cases than in controls (100% Vs 36.7%). There is also a statistically significant difference in blood lead values among smokers and non smokers in both cases and controls. (Cases :smokers 30.55 ± 7.68 μg/dL non smokers 21.36 ± 4.62 μg/dL; Controls : smokers 10.7 ± 1.75 μg/dL, non smokers 4.36±1.49 μg/dL). There is also a statistically significant difference between males and females in both cases and controls [Cases: males 27.73±7.69 μg/dL; females 21.21 ± 5.58 μg/dL ;Controls :males 9.32 ± 3.21 μg/dL ;females 4.41 ± 1.73 μg/dL]. The percentage of those with target organ damage were 40%, 6.3% and 20% respectively for LVH, IHD and retinopathy. There is no correlation between increased blood level between those with and without target organ damage. Animal & human studies have found correlation between blood lead levels and hypertension. In view of the increased industrialization and poor environmental surveillance, it is prudent to explore blood lead levels in hypertensives especially those with chronic low grade exposure.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Primary Hypertension ; Blood Lead Levels. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 15 Mar 2018 03:19 |
| Last Modified: | 15 Mar 2018 03:19 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6222 |
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