Histomorphological evaluation of Esophagus in cases of Gastro Esophageal Reflux Disease and its association with Gastric H. Pylori Infection.

Radhika, A R (2009) Histomorphological evaluation of Esophagus in cases of Gastro Esophageal Reflux Disease and its association with Gastric H. Pylori Infection. Masters thesis, Tirunelveli Medical College, Tirunelveli.


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In the Later Half of the Twentieth Century, Gastro-Esophageal Reflux Disease [GERD] Emerged As The Most Common Upper Gastrointestinal Disease Of The Western World. This Disease is a Major Contributor to the Rise In The War Of Endoscopy And Acid Suppression Therapy. Epidemiolgic Studies Suggest A 3% To 4% Prevalence Of GERD In The General Population With The Preponderance Of Individuals Having Mild Or Moderate Disease. Reflux Esophagitis Results From The Action Of Peptic Juice On The Esophageal Mucosa. Reflux Esophagitis Can Occur In Any Age Group But Is Most Common In The Middle Aged Persons. Risk Factors Include Hiatal -Hernia, Excessive Vomitting And Peptic Ulcer Disease. The Use Of Non - Steroidal Antiinflammatory Agents, Alcohol Abuse, Cigarette Smoking, Diabetes, Systemic Sclerosis And Pemphigus Are Also Associated With Gastro -Esophageal Reflux. Barrett’s Esophagus, Defined As The Presence Of The Columnar Metaplastic Epithelium In The Distal Esophagus Over A Length Of More Than 2 To 3cm Is Usually Considered To Be A Complication Of Long Standing Gastro-Esophageal Reflux Disease [GERD] And Is One Of The Major Manifestations Of GERD. Helicobacter Pylori Is A Gram-Negative, Microaerophilic Bacterium That Inhabits Various Areas Of The Stomach And Duodenum. It Causes A Chronic Low-Level Inflammation Of The Stomach Lining And Is Strongly Linked To The Development Of Duodenal And Gastric Ulcers And Stomach Cancer. Over 80% Of Individuals Infected With The Bacterium Are Asymptomatic. Helicobacter Pylori Has Acquired Great Importance During The Last Two Decades, After Being Recognized As An Important Pathogen That Infects A Great Portion Of The Human Population. Helicobacter Pylori Is Of Major Concern Today Because Of Its Causal Relationship With Gastroduodenal Diseases. The Bacteria Are Prevalent Worldwide And More Than Half Of The World’s Population Are Infected With H. Pylori. Recently, It Has Been Observed That Gastric Colonization With H.Pylori May Also Have Beneficial Effects For The Human Host. In This Respect, The Interest Is In Particular Going To The Potential Preventive Effect Of H.Pylori Colonization On The Development Of Gastro-Esophageal Reflux Disease (GERD) And Its Complications Such As Barrett’s Esophagus And Adenocarcinoma Of The Distal Esophagus. If So, This Will Have A Major Impact On Issues Such As Screening And Treatment Of H.Pylori Infections. By Now, The Potential Role Of H. Pylori In The Development Of GERD Is A Key Issue In The Treatment Of Patients With Upper Gastrointestinal Disorders. GERD Patients With Concomitant H.Pylori Infection Showed More Severe Gastritis In The Antrum Than In Other Parts Of The Stomach, Such As Corpus, Fundus And Cardia. Apart From A Lower Prevalence Of GERD Among H.Pylori-Positives, Some Also Reported That If GERD Is Present In H.Pylori-Positive Subjects, It May Be Less Severe. This Interesting Note Made Us Think To Evaluate The Various Histomorphological Changes Seen In Esophagus In Cases Of GERD And To Correlate The Findings With The Status Of Gastric H Pylori Colonization In Those Cases.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Histomorphological Evaluation ; Esophagus Cases ; Gastro Esophageal Reflux Disease. Association ;Gastric H. Pylori Infection;
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 29 Jun 2017 07:33
Last Modified: 29 Jun 2017 07:33
URI: http://repository-tnmgrmu.ac.in/id/eprint/622

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