Serum Uric Acid Level in Type 2 Diabetes Mellitus

Senthur Raja Pandian, S (2006) Serum Uric Acid Level in Type 2 Diabetes Mellitus. Masters thesis, Madurai Medical College, Madurai.


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Diabetes Mellitus is strongly associated with hyperuricemia. The role of uric acid is a independent risk factor for cardiovascular disease is a matter of controversy. The present study was proposed to asses the uric acid status in patients with diabetes mellitus and to find out its association with age, gender, BMI, WHR, smoking and CAD. With rigid criteria, patients were selected carefully and evaluated on social, clinical, and laboratory aspects after getting institutional, ethical clearance and informed consent. 30 healthy age, sex matched individuals were kept as control. There were 46 males and 24 Females in the study group and 18 males and 12 females in the control group. The mean and standard deviation of age among the patient group was 60.01± 8.82 and 56.27 ± 7.84 in control group. There was no significant difference among cases and controls in relation to age. In study group, BMI below 25 seen in 32 cases (45.7%) BMI above 25 seen in 38 cases (54.3%) which was significantly more than controls. BMI had significantly correlated with hyperuricemia. Similarly WHR was greater among women than men in diabetics, which also correlated with elevated serum uric acid significantly. Elevated serum uric acid level was noticed more among those who had hypertension (21.4%), dyslipidemia (28.6%), Coronary artery disease (21.4%) and they were significant. Patients with longer duration of diabetes also had elevated uric acid level. The factors contribute to hyperuricemia in diabetes are 1. Hyperinsulinemia acutely reduces urinary uric acid and sodium excretion. 2. Hyperinsulinemia imposes a chronic antinatriuretic and antiuricosuric pressure on the kidney. 3. Microvascular disease in diabetes mellitus causes local tissue ischemia, and decreased renal blood flow. Ischemia with associated lactate production that blocks urate secretion in proximal tubules. Increased uric acid synthesis due to increased purine metabolism, ischemia induced increased xanthine oxidase production, insulin resistance, and diuretic use. Meticulous control of blood sugar, hypertension, dyslipidemia, body weight and abdominal girth, form an essential component of diabetes which will bring down uric acid level, a less discussed issue among diabetic population. In view that it is worth to explore uric acid levels atleast in patients with family history of diabetes and in obese diabetic patients to detect early cardiovascular complications.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Type 2 Diabetes Mellitus ; Serum Uric Acid Level.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 15 Mar 2018 02:59
Last Modified: 15 Mar 2018 02:59

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