Punitha, D (2015) Formulation and Evaluation of Levofloxacin Oral Dispersible Tablets. Masters thesis, Annai Veilankanni’s Pharmacy College, Chennai.
|
Text
260111815punitha.pdf Download (2MB) | Preview |
Abstract
INTRODUCTION:Oral disintegrating tablets are solid single unit dosage forms that are placed on tongue, allowed to disperse or dissolve in saliva without the need of water, frequently releasing of the drug for quick onset of action. Oral disintegrating tablets are well accepted by wide range of population especially as pediatric and geriatric patients who have difficulty in swallowing of conventional dosage forms. Some drugs are absorbed from mouth, pharynx and esophagus as saliva passes down to stomach. The bioavailability of such drug will be increase due to first pass metabolism1. Consumer satisfaction is the buzzword of the current millennium, and movement to achieve it has already begun in the pharmaceutical industry. An inability or un willingness to swallow solid oral dosage forms such as tablets and poor taste of medicine are some of the important reasons for consumer dissatisfaction.AIM AND OBJECTIVE:F or the past two decades, there has been enhanced demand for more patient compliance dosage forms. As a result, the demand for their technologies has been increasing three fold annually. Since the development cost of a new chemical entity is very high, the pharmaceutical companies are focusing on the development of new drug delivery systems for existing drug with an improved efficacy and bioavailability together with dosing frequency to minimize side effects. This results in slower dissolution and absorption rates on oral administration and is one of the causes of gastro intestinal side effects Improvement in drug solubility expected to enhance its bioavailability and reduce local side effects Difficulty in swallowing (dysphasia) is a common problem of all age groups, especially the elderly and pediatrics, because of physiological changes associated with these groups. Other categories also several problems in using conventional oral dosage forms include the mentally ill, uncooperative patients suffering from nausea, sudden episodes of allergic attack or coughing. Sometimes it may be difficult to swallow conventional products due to nonavailability of water. These problems led to the development of levofloxacin as mouth dissolving tablets. Which disintegrate and dissolve in saliva without the need of drinking water. The saliva serves to rapidly disperse the dosage form and the dissolved medicament is swallowed along with saliva in normal way. As the dissolved medicaments along with saliva passes down into stomach, they are absorbed from the mouth, pharynx, and oesophagus. Therefore the bioavailability of levofloxacin is significantly greater than those observed from conventional levofloxacin dosage forms.SUMMARY AND CONCLUSION: Oral dispersible Tablets of Levofloxacin were prepared with two different superdisintegrants and evaluation of blend powder, tablets evaluation studies, IR spectral studies, dissolution studies and stability studies were performed .The summary are presented. Preformulation studies such as angle of repose, bulk density, tapped density, compressibility index and hausner ratio were performed and the results showed that all the parameters are within the acceptable limits. Tablets were prepared by direct compression method and evaluated for general appearance, hardness test, uniformity of weight, friability, wetting time, disintegration time, drug content estimation and in vitro release study. All the formulations were found to be good appearance without showing any chipping, capping and sticking defects and all other parameters were passed the test. IR spectroscopic studies indicated that the drug is compatible with all the polymers and there was no drug-polymer interaction. When comparing all the formulations, F7 shows a better drug release of 96.10% at the end of 15 minutes. All the formulations were subjected for stability studies for 45 days at different temperatures such as room temperature, fridge temperature and accelerated temperature (45°C±2°C). At 15 days interval upto 45 days, the drug content and dissolution studies were carried out. There was no significant change in the drug content and invitro drug release. The main objective of the present study was to develop Oral dispersible tablet formulation containing 150mg of Levofloxacin for the treatment of a number of infections including infection of Joints and bones, respiratory tract infections, urinary tract infections, skin structural infections and typhoid fever etc. In the present work it has been observed from all formulations of precompression and post compression studies were given within the limit of values. The in vitro dissolution data, FLOT- 7(combination of different superdisintegrants) formulation was found that the drug release is best and the cumulative % of drug release was 96.10 % respectively, when compared to other formulation.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Levofloxacin ; Oral Dispersible Tablets |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 14 Mar 2018 11:17 |
| Last Modified: | 14 Mar 2018 11:17 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6203 |
Actions (login required)
 |
View Item |
