Formulation and Invitro Evaluation of Escitalopram Oxalate Oral Disintegrating Tablets

Vinodhini, R (2015) Formulation and Invitro Evaluation of Escitalopram Oxalate Oral Disintegrating Tablets. Masters thesis, Annai Veilankanni’s Pharmacy College, Chennai.


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NTRODUCTION:Oral route of drug administration is most appealing route for delivery of drugs of various dosage forms. The tablets is one of the most preferred dosage form because of its ease of administration, accurate dosing and stability as compared to oral liquid dosage forms and when compared to capsules, tablets are more temper evident.TABLETS1:Tablets may be defined as solid unit pharmaceutical dosage forms containing drug substance with or without suitable Excipients and prepared by either compression or molding mehtods1. The first step in the development of dosage form is Preformulation, which can be defined as investigation of physicochemical properties of drug substance alone and when combined with Excipients. The main objective of Preformulation studies, is to develop stable and bioavilabel dosage form and study of factors affecting such stability, bioavailability and to optimize so as to formulate the best dosage form, here optimization of formulation means finding the best possible composition2. compressed tablets are formed by applying pressure, for which compression machines (tablet presses) are used and they are made from powdered crystalline or granular material, alone or in combination with binder, disintegrants, release polymers, lubricants and diluents and in some cases colorant.AIM:To carry out preformulation study of excipients and their compatibility with the API. Development of various formulations and preparation of ODT’s by direct compression technique. Selection and optimization of the best formulation. To conduct accelerated stability testing to the finished dosage form as per ICH guidelines OBJECTIVE OF STUDY:To carry out literature survey of drug molecules To analyse the trial samples To optimize the final formula To conduct the stability studies of final formula SUMMARY:A recent advance in Novel Drug Delivery System aims to enhance safety to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. One such approach is Orally Disintegrating Tablet. The present study was to formulate and standardize of an Anti depressant drug Escitalopram Oxalate. Escitalopram Oxalate orally disintegrating tablets formulated in the present study are beneficial to the pediatrics and elderly patients. It is also beneficial to the person having Dysphagia and mentally ill. Preformulation studies were carried out during the early stages of this work. It was found that Escitalopram oxalate is having maximum absorbance at wavelength 239 nm. The drug-polymer compatibility study was carried out to determine the interactions between the drug and the polymers used in the study. The orally disintegrating tablets were formulated using the above mentioned difrent super disintegrants by direct compression technique. Crospovidone, LHPC-21 and Kyron T-314 were used as super disintegrants . Prepared tablets were evaluated for Pre-Compression Parameters and Post compression Parameters. Flow properties –Angle of repose, Bulk density, Tap Density and also %compressability was determined to all formulations which showed good flow property. Formulation F1 was carried Microcrystalline cellulose (Cyclocel pH112) as diluents, Crosspovidone XL (2.5%) & L-HPC (2.5%) as Superdisintegrants. Aerosil is used as a glident. here shows the DT more than 3mins to improve the disintegration time the addition of the super disintegrants KYRONT-314 ,the disintegration time was improved but still the wetting time and the invitro dispersion time were not improved for this reason the Spray dried Mannitol was used as diluents and concentration of super disintegrants was increased in F3.As the increasing the concentration of the diluents Mannitol results in the good wetting time and invitro dispersion.CONCLUSION:Escitalopram Oxalate used as Antidepressant. They are formulated as oral disintegrating tablets which show better patient acceptability and compliance with improved efficacy when compared with conventional dosage forms. Direct compression was the preferred technology for the preparation of oral disintegrating tablets of Escitalopram Oxalate. Based on the preliminary studies various formulation trials (F1-F9) were carried out with different concentrations of Superdisintegrants, filers and lubricants. From the various formulations it was concluded that the formulation F9, the reproducibility batch of F8 was finalized as the optimized formula. Formulation F9 showed satisfactory results with various physicochemical evaluation parameters like Hardness, Percentage weight loss, Disintegration time, Dissolution profile, Assay and Moisture content. When subjected to accelerated stability studies the tablets were found to be stable.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Invitro Evaluation; Escitalopram; Oxalate Oral ; Disintegrating Tablets
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 14 Mar 2018 11:03
Last Modified: 15 Mar 2018 11:58

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