Formulation and in Vitro Characterization of Ciprofloxacin HCL Floating Tablets

Emil Shirly, T (2015) Formulation and in Vitro Characterization of Ciprofloxacin HCL Floating Tablets. Masters thesis, Annai Veilankanni’s Pharmacy College, Chennai.


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INTRODUCTION:Gastro retentive Drug Delivery System Since the last three decades many drug molecules formulated as Gastro Retentive Drug Delivery System (GRDDS) have been patented keeping in view its commercial success. The bioavailability of drugs with an absorption window in the upper part of the GIT (gastro intestinal tract) is generally limited with conventional pharmaceutical dosage forms. These drugs can be delivered ideally by slow release from the stomach to give a localized effect at the site of action. Improved efficacy is expected for drugs that are used in the treatment of gastric disorders like ulcers and bacterial infections (H.pylori that resides in the antral region of stomach behind the mucosal layer). Many drugs categorized as once-a-day delivery have been demonstrated to have suboptimal absorption due to dependence on the transit time of the dosage form, making traditional extended release development challenging. Therefore, a system designed for longer gastric retention will extend the time within which drug absorption can occur.AIM AND OBJECTIVE: Ciprofloxacin Hcl is commonly known as broad spectrum antibiotic medicine which is used to treat infections caused by gram positive and gram negative microorganism. These also prescribed in treatment of respiratory and urinary tract infections. Ciprofloxacin conventional tablets have been used from long period of time for the treatment of bacterial infections.CiprofloxacinHcl is an acidic drug which is primarily absorbed in stomach. The bioavailability of Ciprofloxacin is 69% and its half life is 4 hours. The present investigation of work is to prepare Ciprofloxacin floating tablets by using polymers like HPMC K4M, Eudragit 100S, guar gum, and the prepared tablets are characterized by using different evaluation parameters like buoyancy lag time, floating time, in-vitro drug release, uniformity of drug content, hardness, friability etc.And the best suited formulation of Ciprofloxacin Hcl is compared with marketed product. To improve half life which shows prolong action of drug in controlled manner for long period in stomach. To increase bioavailability of drug by increasing gastric residue time. Ciprofloxacin floating tablets are used to decrease dose frequency of drug also avoid fluctuations that cost by conventional tablets and also it helps to reduce the adverse effects caused by ciprofloxacin at higher doses.SUMMARY AND CONCLUSION:Hydrodynamically balanced tablets of Ciprofloxacin Hcl can be formulated with an approach to increase gastric residence and thereby improves drug bioavailability to the developed floating tablets of Ciprofloxacin Hcl using natural and synthetic polymer HPMC K4M, Eudragit 100S and guar gum with Sodium bicarbonate combination and citric acid as gas generating agent was prepared by wet granulation technique (F1- F7) was achieved. Preformulation studies for drug such as angle of repose, bulk density, tapped density, compressibility index, Hausner’s ratio were performed and the result showed that all the parameters are within the limits Tablets were prepared by wet granulation method and evaluated for generalappearance, hardness test, friability test, uniformity in weight, drug content estimation. All the formulations were found to be good appearance without showing any chipping, capping and sticking defects and other parameters were also passedthe test. FTIR Spectroscopic studies indicated that the drug is compatible with all excipients and there is no drug- polymer interactions. When comparing all formulation F4 showed optimized drug release of 98.86% at the end of 12 hours. These optimized F4 formulation showed buoyancy lag time of 134 sec. and floating time of.12.5 hrs respectively. Data obtained from kinetic treatment revealed F4 formulations follow Koresmayerpeppas model. The ‘n’ value is 0.861 indicates the non Fickian diffusion. From the comparative study of optimized formulation of Ciprofloxacin Hcl (F4) with marketed product (Cipro XR 500mg) shows that F4 is have greater release than marketed product All the formulations were subjected for stability studies for 45 days at different temperatures such as room temperature, fridge temperature and acclerated temperature (45C2C). At 15 days interval upto 45 days, the drug content and dissolution studies were carried out. There was no significant change in the drug content and invitro drug release From the above study, it was concluded that Ciprofloxacin Hcl can formulated as Floating drug delivery system which helps to increase gastric residence timethere by it increases the bioavailability and half life of Ciprofloxacin Hcl.

Item Type: Thesis (Masters)
Additional Information: Reg.No: 261311053
Uncontrolled Keywords: In Vitro Characterization; Ciprofloxacin; HCL ; Floating Tablets
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 14 Mar 2018 10:54
Last Modified: 15 Mar 2018 11:45

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