Formulation and Evaluation of Sustained Release Microspheres of Rosin Containing Captopril

Gurusankar, R (2012) Formulation and Evaluation of Sustained Release Microspheres of Rosin Containing Captopril. Masters thesis, Periyar College of Pharmaceutical Sciences for Girls, Tiruchirappalli.


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Sustained release dosage form is designed to maintain constant levels of a drug in the patient’s bloodstream by releasing the drug over an extended period. Maintaining constant blood levels of the drug in the bloodstream increases the therapeutic effectiveness of the drug. Drugs are defined precisely under some acts1 . It is the single active chemical entity present in a medicine that is used for diagnosis, prevention, treatment, cure of a disease2. Yet to a common man they are just substances which are administered to win back an individual from the states of disease or ill health to the normal health. The drugs also had mysterious origins and hence the word drug was a form of the word called ‘drogues’ meaning of mysterious origin. The word disease can be expressed as a combination of ‘dis’ and ‘ease’ indicating absence of easine ss or well being or a feeling contrary to the feeling of health. In this study sustained release Captopril Microspheres were prepared successfully using solvent evaporation method. It may be concluded that Captopril microspheres would be promising drug delivery system for oral administration of Captopril to sustained the drug release upto 12 h. The formulation was found to be efficient with good recovery yield, percentage drug entrapment. FT-IR studies did not reveal any significant drug interactions. Captopril microspheres are promising pharmaceutical dosage forms by providing sustained release drug delivery systems and avoiding the dose related side effects in the entire physiological region. Among the different formulations, microspheres containing F-5 was found to be it has higher release the drug of 89.83 ± 0.21 % at 12th hour. The diffusion of F5 formulation follows Zero order kinetics and fit into the orsemeyer- peppas model and follows non-fickian, Formulating Captopril microspheres (F5) was uccessfully achieved. The drug release in a sustained manner upto 12 hours with less dose dumping.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Formulation ; Evaluation ; Sustained Release Microspheres ; Rosin Containing Captopril.
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 29 Jun 2017 06:22
Last Modified: 16 May 2018 00:39

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