Expression of Bcl-2 and Ki-67 in Endometrial Lesions.

Nilavu, J (2013) Expression of Bcl-2 and Ki-67 in Endometrial Lesions. Masters thesis, Coimbatore Medical College, Coimbatore.


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The Human Endometrium Shows Dynamic Morphological Changes During The Menstrual Cycle In Reproductive Women. These Cyclical Changes Include Cell Proliferation With High Mitotic Activity, Secretory Changes And Shedding Of Endometrial Cells Regulated By Ovarian Sex Steroids. There Should Be Some Inhibitory Mechanism To Counterbalance Such Proliferation To Maintain Tissue Homeostasis. Thus Apoptosis Which Is Programmed Cell Death Is Critical In Regulation Of The Menstrual Cycle. There Should Be A Balance Between The Apoptotic And Mitotic Activity For The Regulation Of Normal Menstrual Cycle. The Aim Of This Thesis Is To Study The Apoptotic And Mitotic Activity In The Endometrium Of Various Lesions Which Includes Cyclical Endometrium , Endometrial Hyperplasias, Premalignant Conditions And Malignancy. This Is Determined Immunohistochemically By Using Markers Such As Bcl-2 And Ki-67. Bcl-2 Is An Anti-Apoptotic Gene Involved In The Regulation Of Apoptosis And Ki-67 Is A Recognized Indicator Of Cell Mitotic Activity. Increased Expression Of Both Indicates Tumorigenesis. Thus The Pattern Of Expression In Hyperplastic And Premalignant States Of Endometrium Helps Us To Study The Progression Of These Conditions To Frank Malignancy.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Expression ; BCl-2 ; Ki-67 ; Endometrial Lesions.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 29 Jun 2017 07:24
Last Modified: 29 Jun 2017 07:24

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