Kalpanadevi, M (2012) Formulation and Evaluation of Proniosomal Transdermal Patches of Glipizide. Masters thesis, Nandha College of Pharmacy, Erode.
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Abstract
In the past few decades, extensive attention has been focused on the growth of new drug delivery system. The significant of NDDS, it should be deliver the drug at a rate directed by the needs of the body, over period of time. A number of NDDS have emerged encompassing various route of administration to achieve controlled and target drug delivery. Recently different types of carrier system s and technologies have been briefly studied with the aim of controlling the drug release and improving the worth and selectivity of formulation. And to minimize drug degradation and loss, to prevent the harmful side effects and increased the bioavailability and the fraction of the drug accumulate in the required zone, various drug delivery and drug targeting systems are developed. The targeting is the capability to direct the drug two major mechanisms can be notable for desire sites for drug release (1) passive, (2) active targeting controlled release. This project was design to investigate the chance of manufacturing to Proniosomal gel transdermal patches. The result indicated the Proniosomal gels were very promising drug carriers. The present formulation study on glipizide is an effort to prepare Proniosomal gel converted into the transdermal patches and to evaluate the performance. The content of nonionic surfactant and cholesterol is evaluated in this study. The best formulation of Proniosomal gel was one which have high efficiency is found to be surfactant and cholesterol content dependent. The release rate is also depending upon surfactant and cholesterol content. The FT-IR studies indicated no chemical interactions between drug, other exicipients and stability of drug during the method of preparations. The formulation F2 which shows higher entrapment efficiency was 92.75%. In-vitro release study of F2 shows release 98.710% and drug permeation 39.325μg/cm2 at the end of 24 hrs which shows sufficient release of drug in phosphate buffer. The in-vitro release data applied to various kinetic models to predict the drug release kinetics. Values were obtained from Higuchi’s, Peppa’s plot verifies result to Diffusion mechanism and zero order kinetics. By this facts study can be concluded the Proniosomal gel transdermal patches showed controlled drug release properties. The combination of cholesterol and surfactant ratios was to produce sustained release of over a long period of 24 hours for the management of diabetics. This Proniosomal transdermal patches as a device, penetrate to the skin barrier along to the skin moisture gradient. This Proniosomal gel is containing component that stabilize the lipid bi layer and thus important to comfortable vesicle.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Formulation ; Evaluation ; Proniosomal ; Transdermal Patches ; Glipizide. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 29 Jun 2017 05:40 |
| Last Modified: | 16 May 2018 01:07 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/609 |
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