Sathish Kumar, M (2013) A Prospective study of Various CNS Manifestations Associated with HIV/AIDS and to study a relationship between it and CD4 counts. Masters thesis, Thanjavur Medical College, Thanjavur.
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Abstract
BACKGROUND : AIDS is a disease caused by human immunodeficiency virus and featured by immunosuppression leading on to opportunistic infection secondary neoplasm’s and neurological manifestations. According to WHO HIV is a pandemic. The mortality due to opportunistic infection is more. The opportunistic infection occurred when there was a decrease of cd4 counts. METHODS : A prospective study was conducted in Thanjavur medical college thanjavur with an objective to determine the various CNS manifestations associated with HIV and its relation with the CD4 counts. All the seropositive aged more than 14 yrs with CNS manifestations where included in the study. Clinical examinations, CT, MRI, serology, CSF analysis were done and diseases where diagnosed based on respective criteria’s. CD4 counts where done and co related with the diagnosis. A total of 40 cases were studied. RESULTS : The infection was common among males. The people aged between 30-39 where affected the most. Tuberculosis was the most common infection. Toxoplasma and tuberculoma presented with focal neurological signs. One case of progressive multifocal keukoencephalopathy was observed, he presented with seizures. Seizure was also seen with toxoplamosis and neurocysticercoisis. Most of qall the cases had headache as the commonest symptom. CNS TB had mean CD4 count of 217, cyptococcal meningitis had a mean count of 130, toxoplasmosis with a mean count of 104, PML with 286.Two cases of stoke were observed and it was attributed to direct virus infection and they had a mean count of 323. Three cases of the 22 tb cases had TB lymphadenitis, intestinal TB AND TB pericarditis. CONCLUSION : The various cns manifestations studied were TB meningitis, cryptococcal meningitis, tuberculoma, toxoplasmosis, PML, stoke, ATM. TBM was the most common infection observed. TB occurred over a range of CD4 counts so cannot be used as a AIDS defining illness. The mortality for CNS TB was more when it occurred with low CD4 counts. Headache was the most common presentation.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | CNS Manifestations ; HIV/AIDS ; CD4 counts ; Prospective study . |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 06 Mar 2018 07:06 |
| Last Modified: | 06 Mar 2018 07:06 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6057 |
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