Cystatin-C in Acute Kidney Injury

Jaganathan, P (2013) Cystatin-C in Acute Kidney Injury. Masters thesis, Thanjavur Medical College, Thanjavur.


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INTRODUCTION : Acute kidney injury is associated with increased mortality of around 45% to 60%. Early diagnosis and initiation of dialysis can prevent progression and decrease mortality in patients with acute kidney injury. However, serum creatinine , the standard marker to detect AKI demonstrates major limitations. In this study, We prospectively evaluated the role of cystatin C in detection of AKI and whether it can detect AKI earlier than serum creatinine. AIMS AND OBJECTIVES : 1. To evaluate the role of cystatin-C as a biomarker for the early detection of AKI. 2. To compare the predictive ability of cystatin-C with serum creatinine level in early prediction of AKI. 3. To assess the correlation of cystatin-C level with the severity and outcome of AKI. MATERIALS AND METHODS : Single Center, prospective observational study at Thanjavur Medical College. 60 patients at risk of developing AKI were studied. RESULTS : Following results were obtained, Cystatin C levels predicts AKI better than serum creatinine level. Cystatin C levels can predict AKI earlier than serum creatinine value. It can predict AKI atleast 1 or 2 days earlier than serum creatinine. CONCLUSION : Serum cystatin C is a sensitive bio-marker for AKI and it can predict AKI earlier than serum creatinine.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Acute kidney injury ; cystatin C ; creatinine.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 06 Mar 2018 06:26
Last Modified: 06 Mar 2018 06:26

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