A Correlative Study on Bone Marrow Angiogenesis with Bone Marrow Fibrosis and Splenomegaly.

Anbulenin, K (2013) A Correlative Study on Bone Marrow Angiogenesis with Bone Marrow Fibrosis and Splenomegaly. Masters thesis, Coimbatore Medical College, Coimbatore.

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Abstract

Myelofibrosis Is Defined As The Pathological Process Characterized By Increased Deposition Of Collagen Type I And Type Iii In The Bone Marrow Secondary To Release Of Fibroblast Growth Factors. Fibroblast Growth Factors Include Pdgf,Epidermal Growth Factor,Endothelial Growth Factor,Tgf–Beta.These Factors Are Present In The Alpha–Granules Of Megakaryocytes. Bone Marrow Fibrosis Usually Results From Increased Stimulation Of Fibroblasts Secondary To Release Of Tumour Necrosis Factor Alpha , Il1alpha And Il–1beta Which Are Produced By Bone Marrow Cells. Fibroplasia Is Usually Associated With Increase In Blood Flow Through The Marrow Of Intramedullary Hematopoiesis,Resulting In Extramedullary Hemopoiesis Which Frequently Affects Liver And Spleen. Extramedullary Hematopoiesis Is Associated With Poor Prognosis.Hence Studying The Correlation Of Fibroplasia,Spleen Size And Marrow Angiogenesis May Be Helpful In Predicting Disease Outcome And The Patients Survival.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Correlative Bone Marrow Angiogenesis ; Bone Marrow Fibrosis ; Splenomegaly.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 29 Jun 2017 07:19
Last Modified: 29 Jun 2017 07:22
URI: http://repository-tnmgrmu.ac.in/id/eprint/604

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