Study of testosterone levels in men with type 2 diabetes mellitus

Asir Julin, P (2013) Study of testosterone levels in men with type 2 diabetes mellitus. Masters thesis, Chengalpattu Medical College, Chengalpattu.


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BACKGROUND : Diabetes Mellitus, one of the most common non- communicable diseases, is a chronic metabolic disorder which is heralded by a number of micro-vascular and macro-vascular complications which are well known of. But the other endocrinological perspective of diabetes is often not given much importance. Most diabetics are associated with low levels of testosterone. Yet this aspect is not often investigated mainly because hypotestosteronemia is usually attributed to the aging process rather than diabetes itself. Moreover the symptoms of hypotestosteronemia are mostly non-specific, further making the diagnosis more elusive. The purpose of our study is to bring forth this association between type 2 diabetes mellitus and hypotestosteronemia. METHODOLOGY : We started the study with the selection of cases and controls. We selected 100 diabetic men from our Diabetology OPD, Chengalpattu Medical College who fitted into the inclusion criteria as our cases. As controls, we selected subjects without history of diabetes mellitus whose FBS was less than 126 mg/dl on two occasions, from our male Medical OPD. Anthropometric measurements like height, weight, waist and hip circumferences were measured and BMI and Waist Hip ratio were calculated. Total cholesterol was measured. Total testosterone in the early morning (8:00–10:00 AM) was measured using CLIA (Chemiluminescence enzyme immunoassay) method. The average serum testosterone levels were compared between the diabetic and non-diabetic men and was statistically analysed. The diabetic patients were further grouped, based on the duration of diabetes, BMI, cholesterol levels and presence or absence of associated risk factor and analysed. RESULT : It was observed that on comparing the average total testosterone level between the two groups, we found that, there was a significant decrease in the testosterone levels in the diabetics compared to that of the non-diabetics in each age group. We also found that as the age progress there is a steady decline in the serum levels of testosterone in both the groups. But the fall in the testosterone values is much more significant in the diabetics. Statistical analysis was made and the P values were calculated by the student T- test. The association between the diabetic and non-diabetics in each age group was found to be significant with a P-value of <0.05. Thus the decrease in the serum level of testosterone is found to be significant. As the second part of our study we compared the serum testosterone levels among the diabetic men, by separating them into smaller groups, using multiple parameters such as duration of diabetes, BMI, Waist Hip ratio, cholesterol levels, associated other risk factors. We were able to derive an inverse relation between serum testosterone levels and most of these parameters. Thus we also evaluated the effects of multiple risk factors on diabetic men and testosterone levels. CONCLUSION : Thus, through this study we demonstrate the association between type 2 diabetes mellitus and testosterone. We conclude that, there is a significant reduction in the levels of serum testosterone in diabetic men as compared to that of non-diabetic men. Even though the declining trend of the testosterone levels occurs as the age increases the reduction in the testosterone levels are more significant in the diabetic group as compared to that of the non-diabetic men. Thus from our study we propose that age factor alone is not the cause of hypotestosteronemia in diabetes men. From the analyses of different factors like BMI, cholesterol and other risk factors we have shown the influence of multiple factors on the levels of testosterone. Thus, in diabetic patients, hypotestosteronemia is a common entity. We suggest the measurement of testosterone in patients with diabetes, as the replacement of testosterone can have multiple benefits in diabetic patient to prevent diabetic complication and cardiovascular diseases. Testosterone level can further predict the development of type 2 diabetes mellitus, the utilization of this aspect of testosterone in future, is not too far.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Type 2 diabetes mellitus, testosterone, risk factors, Body mass index.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 06 Mar 2018 01:25
Last Modified: 06 Mar 2018 01:25

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