Nivedita, M (2016) Formulation and Evaluation of Diacerein Loaded Microsponges in Capsule. Masters thesis, College of Pharmacy Madras Medical College, Chennai.
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Abstract
INTRODUCTION:The aim of the Novel drug delivery system is to provide a therapeutic amount of drug to the appropriate site in the body to accomplish promptly and then maintain the desired drug concentration. The drug delivery system should deliver drug in rate controlled manner in the body over a specific term of treatment. This idealized objective switches to the two main aspects they are as follows I. Spatial drug delivery Targeting a drug to a particular organ or tissue. II.Temporal drug delivery Drug delivery rate to target tissue is controlled.AIM OF WORK:1. To formulate Diacerein microsponges using Eudragit RS 100 and Ethyl Cellulose polymers. 2. To study the effect of Concentration of External phase, amount of Internal phase and stirring rate on optimised formulation. 3. To enclose Diacerein microsponges in Hard gelatin Capsules. The objective of current work is to enhance the rate of solubility of the drug thus to augment bioavailability and to release the drug in a controlled manner to improve the efficacy and patient compliance.PLAN OF WORK:The present work was planned to carry out the Formulation and evaluation of Microsponges loaded with Diacerein as model drug. The design of work: I. Compatibility studies 1. Physical compatibility study. 2. Chemical compatibility study. II. Preparation of Standard graph for Diacerein. III. Formulation and development
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Diacerein Loaded Microsponges ; Capsule |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 02 Mar 2018 09:03 |
| Last Modified: | 06 Mar 2018 12:03 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5990 |
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