Codestm Drug Delivery: Capecitabine in the Management of Colorectal Cancer

Suganya, G (2017) Codestm Drug Delivery: Capecitabine in the Management of Colorectal Cancer. Masters thesis, PSG College of Pharmacy, Coimbatore.


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INTRODUCTION:Cancer is a general term used to refer to a condition where the body cells begin to grow and reproduce in an uncontrollable way. These cells can then invade and destroy healthy tissue, including organs. Cancer sometimes begins in one part of the body before spreading to other parts. Cancer is a common condition and a serious health problem. More than one in three people will develop some form of cancer during their lifetime. There are hundreds of different types of cancer. In 2012 about 14.1 million new cases of cancer occurred globally. It caused about 8.2 million deaths or 14.6% of human deaths. The most common types of cancer in males are lung cancer, prostate cancer, colorectal cancer and stomach cancer. In females, the most common types are breast cancer, colorectal cancer, lung cancer and cervical cancer. Treatment for cancer will depend on many factors. Such as the stage and location of the disease it includes the surgery, chemotherapy, radiation therapy. Possible sign and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss and a change in bowel movements. While these symptoms may indicate cancer, they may have other causes over 100 types of cancers affect humans. Cancers harms the body when altered cells divide uncontrollably to form lumps or masses of tissue called tumors. Tumors can grow and interfere with the digestive, nervous and circulatory system.AIM:To prepare and evaluate chitosan nanoparticles loaded capecitabine drug formulation used for colorectal cancer.OBJECTIVES:To prepare capecitabine nanoparticles by ionic gelation method. 1. To study the particle size and morphology of prepared capecitabine nanoparticles. 2. To formulate prepared nanoparticles into tablets. 3. To evaluate the tablets. 4. To study the in-vitro release of prepared tablets.CONCLUSION:The study concludes that the drug capecitabine in nanoparticulate drug delivery system of ionic gelation technique yields 474.4 nm nanosize of particles with good zeta potential and SEM analysis also confirms the surface morphology of nanoparticles with cubic shape. The prepared capecitabine nanoparticles were taken along with magnesium stearate and talc was taken as excipients for preparation of tablets by direct compression method. Evaluation of tablets such as weight variation test, Hardness test, Thickness test, Friability test and disintegration test was carried out and shown that the tablets were within the limit. In -vitro dissolution study was performed for tablet and the release showed 59.4% at end of the 8 hours to target the colon. For release data, drug release kinetics was performed such as zero order kinetics, first order kinetics, Higuchi release and Korsmeyer peppas model. Further, cell line study was carried out using HT 29 (Colon carcinoma) cells. This study confirmed, the formulation showed better cytotoxic activity than capecitabine drug solution.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Codestm Drug Delivery; Capecitabine ; Colorectal Cancer
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 02 Mar 2018 06:31
Last Modified: 02 Mar 2018 06:31

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