Formulation And Evaluation of Nimodipine Sublingual Tablets

Shaik Bajid Basha, - (2015) Formulation And Evaluation of Nimodipine Sublingual Tablets. Masters thesis, Annai Veilankanni’s Pharmacy College, Chennai.

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Difficulty in swallowing (dysphagia) is a common problem of all age groups, especially the elderly and pediatrics, because of physiological changes associated with these groups. Other categories that experience problems using conventional oral dosage forms include are the mentally ill, uncooperative and nauseated patients, those with condition of motion sickness, sudden episodes of allergic attack or coughing. Sometimes it may be difficult to swallow conventional products due to unavailability of water. These problems led to the development of a novel type of solid dosage form called sublingual tablets, which disintegrate and dissolve rapidly in saliva without the need of drinking water. They are also known as fast dissolving tablets, melt-in-mouth tablets, rapimelts, porous tablets, orodispersible tablets, quick dissolving tablets or rapidly disintegrating tablets. Upon ingestion, the saliva serves to rapidly dissolve the dosage form. The saliva containing the dissolved or dispersed medicament is then swallowed and the drug is absorbed in the normal way. Some drugs are absorbed from the mouth, pharynx, and oesophagus as the saliva passes down into the stomach. In these cases, the bioavailability of drugs is significantly greater than those observed from conventional dosage forms.AIM:In the present work an attempt will be made to formulate nimodipine sublingual tablets, using different superdisintegrants for treatment of hypertension, the fast dissolving tablet provides a rapid onset of action.OBJECTIVE:1. To design the formula for sublingual tablet. 2. To selected model drug and develop formula and prepare tablets. 3. To evaluate the formulated tablets. 4. To study the in-vitro dissolution profile of prepared tablets. 5. To carry out stability studies of the selected formulations.SUMMARY:The aim of the present study was to develop and optimize oral sublingual tablets of model drug (NMD) to give quick onset of action by rapidly disintegrating in a few seconds without the need of water with better patient compliance. In such cases, bioavailability of drug is significantly greater and adverse event is reduced than those observed from conventional tablet dosage formTHE WORK DONE IS SUMMARIZED AS FOLLOWS:By performing compatibility studies by IR spectrophotometry, no interaction was confirmed. Oral disintegrating tablets were formulated by direct compression method and suitable analytical method based on UV-Visible spectrophotometer was developed for the model drug Standard calibration curve prepared to determine the drug content in the prepared tablets and UV analysis was performed to determine the drug during in vitro release studies. Prior to compression, the blend of drug and excipients were evaluated for flow properties such as Angle of repose, loose bulk density, Tapped density, % Compressibility, and Hausner’s ratio. All the formulations showed good flow properties. Sublingual tablets were prepared by direct compression technique using CADMACH 16 station tablet punching machine, equipped with flat round punch of 8.7 mm diameter. Post compression evaluation of prepared sublingual tablets were carried out with the help of different pharmacopoeial and non pharmacopoeial (industry specified) tests. The shape and colour of all the formulations were found to be circular and white in colour. The thickness was found to be uniform in specific formulations. The hardness and friability are also within the permitted limits.CONCLUSION:Sublingual tablets of nimodipine can be successfully prepared by direct compression method using selected superdisintegrants with Crosspovidone 1.5%, 3%, 6%, Crosscarmellose 1.5%, 3%, 6% and Sodium starch glycolate 1.5%, 3%, 6%, for the better patient compliance and effective therapy the relative efficiency of these superdisintegrant to improve the disintegration and dissolution rate of tablets were found in order The disintegration of F1, F2, F3 with 1.5%, 3%, 6% Crosspovidone formulations to be as 8, 6, 5secs respectively and is almost better than F4, F5, F6, F7, F8, F9 formulations Formulation F3 In-vitro Dissolution studie 10 minutes almost total amount of the drug is released 6% crosspovidone (i.e. 96.96%). Crosspovidone shows good result as compare to other superdisintegrants. Crosspovidone > crosscarmellose sodium > sodium starch glycolate

Item Type: Thesis (Masters)
Uncontrolled Keywords: Nimodipine Sublingual Tablets ; Crosspovidone
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 02 Mar 2018 06:32
Last Modified: 02 Mar 2018 06:32

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