Mekala, A (2009) Narrow Band UVB and PUVA Therapy: A Comparative study in patients with chronic plaque type psoriasis. Masters thesis, Madurai Medical College, Madurai.
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Abstract
INTRODUCTION : The importance of sun light has been recognized since ancient times. Ultra violet light is a small component of electromagnetic spectrum with narrow band of radiation from 200 – 400nm. The ultra violet spectrum is further divided into 1) Ultra violet C (200-280nm), 2) Ultra violet B (280-315 nm) and 3) Ultra violet A (315-400 nm). Artificial UV radiation that allows precise dosing has only been available for the last century. The phototherapy is a well understood, time proven method for achieving remission in majority of cases. It is a relatively safe method for treatment of :- • Psoriasis poorly responsible topical treatment. • Rapidly spreading psoriasis. • Wide spread psoriasis (over 20 % of body surface). • Severe psoriasis of palms and soles. AIM OF THE STUDY : This study is conducted in patients with chronic plaque type psoriasis, 1. To evaluate the efficacy, side effects and cumulative dose of Narrow Band UVB Phototherapy. 2. To evaluate the efficacy, side effects and cumulative dose of PUVA phototherapy. MATERIALS AND METHODS : The material for this study was from the patients with chronic plaque type psoriasis, attending the skin OPD, Government Rajaji Hospital, Madurai Medical College, Madurai, during June 2007 – May 2008. The diagnosis of Psoriasis was made on clinical grounds INCLUSION CRITERIA : Patients with chronic plaque type psoriasis involving greater than 20% of the body surface area. EXCLUSION CRITERIA : For NB-UVB Group : • Photosensitive disorders • Previous History or family history of malignant melanoma • History of skin cancers or photodamage • History of exposure to inorganic arsenic or ionising radiation For PUVA Group : • Age less than 18 years. • Pregnant and lactating women. • Photosensitive disorders • Previous History or family history of malignant melanoma. • History of skin cancers or photodamage. • History of exposure to inorganic arsenic or ionising radiation. • Significant hepatic, renal or cardiac dysfunction. • Chronic alcoholics. • Active infections like tuberculosis. • Cataract. All patients were explained about the disease and the benefits and side effects of therapy were discussed with them. Consent was obtained from all patients before initiation of therapy. CONCLUSION : NB-UVB phototherapy is superior when compared to PUVA in the treatment of plaque type psoriasis. • The response to therapy is better with NB-UVB than with PUVA therapy. • The therapeutic effect of NB-UVB is achieved with significantly lower cumulative dose which means a lower risk for incidence of long term complication, with special reference to skin malignancy. • NB-UVB is more convenient for the patient and is less time consuming. • No exogenous photosensitizer is used NB-UVB therapy, thus prevents the side effect of psoralen. • No need for eye and skin protection after the session in NBUVB phototherapy. • It can be used in pregnancy, lactation and it is useful and well tolerated treatment for children, but concerns remain regarding its long term side effects.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Narrow Band UVB and PUVA Therapy ; Comparative study ; patients ; chronic plaque type psoriasis. |
| Subjects: | MEDICAL > Dermatology Venereology and Leprosy |
| Depositing User: | Subramani R |
| Date Deposited: | 02 Mar 2018 03:16 |
| Last Modified: | 03 Mar 2018 02:05 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5968 |
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