Murali, B M (2012) Formulation and Development of Olmesartan Medoxomil Immediate Release Tablets. Masters thesis, K K College of Pharmacy, Chennai, Tamil Nadu, India.
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Abstract
Tablets may be defined as solid pharmaceutical dosage forms containing drug substances with or without suitable diluents and prepared either by compression or molding methods. They have been in widespread use since the latter part of the 19th century and their popularity continues. The term compressed tablet is believed to have been first used by ‘John Wyeth and Philadelphinn’. During the same period molded tablets were introduced to be used as Hypodermic tablets for injections. Olmesartan medoxomil tablets were formulated by wet granulation method using lactose monohydrate as diluent, MCC as diluent, povidone as binding agent, crospovidone, croscaramellose sodium & sodium starch glycolate as super disintegrating agents and colloidal silica as glidant, magnesium stearate & stearic acid as lubricant with good release profile for a specified period of time up to 1hr. Compatibility studies were carried out for the physical mixture and the drug was found to be compatible with all excipients used in different formulations. The granulation was compressed into tablets and were analysed for the parameters such as average weight, friability, thickness, hardness, disintegration and assay. Formulation containing crospovidone (14mg) shows rapid rate of disintegration and dissolution when compared with other formulations. The invitro dissolution profiles of F1 to F10 were found to have different percentage of drug release. The disintegration time for F8 tablets was relatively low (0.39min) and dissolution profile (99.5±0.15%) at the end of 60min. when compared to other formulations, F8 has better release profile and concluded that F8 was better formulation product. The stability studies were conducted for F8 tablets for 3 months, which were found to be stable and concluded that formulation F8 was better stable product with good quality
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Formulation; Development; Olmesartan Medoxomil; Immediate Release Tablets |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 29 Jun 2017 03:51 |
| Last Modified: | 29 Jun 2017 03:51 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/596 |
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