Evaluation of Haematological Abnormalities in Decompensated Chronic Liver Disease Patients

Vijay, T (2008) Evaluation of Haematological Abnormalities in Decompensated Chronic Liver Disease Patients. Masters thesis, Coimbatore Medical College, Coimbatore.


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50 patients of decompensated chronic liver disease patients were studied. 1. Almost 80% of the patients had anemia in any one of the form. 2. Most common anaemia in cirrhosis is normochromic normocytic anemia as inferred from the study (52 %). 3. Microcytic anaemia is found in 30% of studied population. 4. Macrocytosis (16%) is almost common with alcoholics. 5. Abnormal red cells such as microcytic, microcytic, target cells, anisocytosis are found to be common in cirrhosis. 6. Leucopenia (6%) is found to be rare as per the study and Leukocytosis is more common in patients with spontaneous bacterial peritonitis and secondary peritonitis. 7. Thrombocytopenia is present is more than 30% of patients and is commonly present in the patients with Splenomegaly and with the history of bleeding tendencies. 8. Prothrombin time prolonged in 46% of the patients. A significant rise in APTT with severe thrombocytopenia is found is DIC patients. CONCLUSION : 1. The most common anemia in cirrhotics is normochromic normocytic anemia. Microcytosis occur in patients with bleeding tendencies and macrocytosis occurs mostly in alcoholics. 2. Leucopenia occurs in a small fraction of patients and Leukocytosis occurs in patients with history of repeated paracentesis and peritonitis. Eosinophilia is associated with parasitic infections. 3. Thrombocytopenia is present in most of the cirrhosis patients and is associated with increased bleeding tendencies. 4. Increased prothrombin time and APTT due to decreased synthesis of clotting factors. 5. All the cirrhosis patients must be evaluated for hematological and haemostatic abnormalities. Early treatment to correct these co morbidities can decrease the mortality.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Haematological Abnormalities ; Decompensated Chronic Liver Disease Patients.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 17 Feb 2018 17:50
Last Modified: 17 Feb 2018 17:50
URI: http://repository-tnmgrmu.ac.in/id/eprint/5826

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