Serum Fibrinogen Levels in Acute Ischemic Stroke

Karthik Pandian, K S (2008) Serum Fibrinogen Levels in Acute Ischemic Stroke. Masters thesis, Coimbatore Medical College, Coimbatore.


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This study was carried out on 50 subjects who presented with ischemic stroke and got admitted in the medical intensive care unit between oct 2005 – 07. Serum fibrinogen level was estimated by using clauss method. The mean level of fibrinogen obtained in patients with stroke was 3.91 gms/l and the control group was 2.71 gms/l in our study. In this study we found that serum fibrinogen level is significantly higher in patients with ischemic stroke compared to controls. . ( odds ratio – 272.332, 95% CI between 32.76 and 2263.7, p value < .001). Serum fibrinogen level in this study was found to be an important risk factor in ischemic stroke. Literature review in connection with the study revealed many studies which demonstrated the independent effects of increased fibrinogen level as one of the risk factor for ischemic stroke. A definite association exists between fibrinogen and atherothrombogenesis. However, the nature of the link is unclear. Although epidemiological and clinical studies suggest that the link is causal, no definite evidence exists. It appears that fibrinogen concentration and plasma viscosity are at least as predictive of coronary events as are cholesterol concentration, diastolic blood pressure and body mass index. Encouragingly, plasma fibrinogen is partly a modifiable risk factor, and suitable lifestyle changes usually result in favourable decreases in plasma fibrinogen levels, although drug therapy has not been fully validated. The relationship between genetic polymorphism in the fibrinogen gene and cardiovascular risk is very complex. Although polymorphisms in the fibrinogen gene could potentially augment the cardiovascular risk through increased fibrinogen levels, the effect appears to be antagonized by some unknown mechanism due to the same polymorphism. Therefore, polymorphisms of fibrinogen gene may modify the effect of external influences on the final phenotype (i.e. the vascular risk) rather than directly affecting the risk of the disease through plasma fibrinogen levels. In future, gene environment interactions should be considered in evaluating the relevance of genetic variations on the risk of cardiovascular disease Future directions require determination of the ‘critically elevated’ fibrinogen threshold value, development of drugs that would specifically and safely decrease plasma fibrinogen levels and conduction of interventional trials to study the influence of lowering fibrinogen levels on overall cardiovascular risk profile.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Serum Fibrinogen Levels ; Acute Ischemic Stroke.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 17 Feb 2018 16:51
Last Modified: 17 Feb 2018 16:51

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