A Study on ‘hs C Reactive Protein’ as Predictive Marker of Cardiovascular Events in Diabetic Renal Disease Patients

Suganya, D (2007) A Study on ‘hs C Reactive Protein’ as Predictive Marker of Cardiovascular Events in Diabetic Renal Disease Patients. Masters thesis, PSG Institute of Medical Sciences and Research, Coimbatore.


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INTRODUCTION : A decade ago, the treatment of hypercholesterolemia and Hypertension was expected to eliminate CAD by the end of the 20th century. Lately, however, that optimistic prediction has needed revision. Cardiovascular diseases are expected to be the main cause of death globally Within the next 15 years owing to a rapidly increasing prevalence in Developing countries and Eastern Europe and the rising incidence of obesity, Diabetes and Diabetes related complication like chronic kidney disease (CKD) in both the developing world and the Western world. Cardiovascular diseases cause 38 percent of all deaths in North America and are the most common cause of death in European men under 65 Years of age and the second most common cause in women. These facts force us to revisit cardiovascular disease and consider new strategies for prediction, prevention, and treatment. AIM : We set out to investigate the hypothesis that elevated C-reactive protein (CRP) levels a marker of an (altered immune response) inflammation, would correlate with coronary artery disease in patients with diabetic chronic renal disease. MATERIAL AND METHODS : This study is of Observational Study Design. Inclusive of a total 50 patients. Between 2004 – 2006 at P.S.G. Institute of Medical Sciences and Research. Inclusion Criteria: Patients with Stage 1 to stage 3 chronic kidney disease (according to NKF- DOQI Guidelines)of Diabetic etiology. Diabetes mellitus both type 1 and type 2. Exclusion Criteria: • Advanced stages of renal disease. • Congestive cardiac failure. • Hypoproteinemia. • Inter current infection in the past 3 weeks. • Connective tissue disorder. RESULTS : Characteristics of the Cases and their Relationship with Cardiovascular Events. There is no statistically significant between the mean age of patients with cardiovascular events and normal cases. DISSCUSSION : 1. Our data suggest that the elevated C-reactive protein level is a predictor of cardiovascular events in Diabetic Renal Disease population. Unlike other markers of inflammation (ICAM, IL-6etc), C-reactive protein levels are stable over long periods, have no diurnal variation, can be measured inexpensively with available high-sensitivity assays, and have shown specificity in terms of predicting the risk of cardiovascular disease. 2. C-reactive protein is a stronger predicter of cardiovascular events than the LDL cholesterol level. The same was suggested by Paul M Ridker and Co-workers and several other workers also and our study demonstrates the same observation(33).THE addition of crp to standard cholesterol evaluation may thus provide a effective and inexpensive and non invasive method to improve clobal risk prediction and compliance with approaches. 3. Tighter glycemic controls are associated with better cardiovascular outcomes. CONCLUSION : CRP level is independently associated with Coronary artery disease in our study group of Diabetic CKD patients and is useful predictive marker for Cardiovascular events (IHD)in the study population.

Item Type: Thesis (Masters)
Uncontrolled Keywords: hs C Reactive Protein ; Predictive Marker ; Cardiovascular Events ; Diabetic Renal Disease Patients.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 17 Feb 2018 16:30
Last Modified: 17 Feb 2018 16:30
URI: http://repository-tnmgrmu.ac.in/id/eprint/5813

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