Sarfaraz Ahmed, T A (2012) A Study on role of spot urine protein creatinine ratio in quantification of proteinuria. Masters thesis, Government Mohan Kumaramangalam Medical College, Salem.
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Abstract
BACK GROUND : Persistent proteinuria is usually a marker of kidney damage. Quantifying protein in urine is commonly used in the diagnosis of kidney diseases, detection of treatment effects and evaluation of prognosis. Commonly used methods to quantify proteinuria is 24 hours urine collection, which is time consuming cumbersome and often in accurate. The other method of quantifying proteinuria is from Protein-Creatinine ratio. OBJECTIVES : The study was to compare spot urine protein- creatinine ratio with 24 hours urine protein in the quantitative assessment of proteinuria in patients with varying degrees of renal dysfunction. This study also attempts to assess the best timing for collection of urine for estimation of protein creatinine ratio. METHOD : 55 patients with persistent dipstick positive proteinuria with varying degrees of renal dysfunction were included in this study. Two urine samples were collected ,one in the early morning(around 7AM) and other in the evening (7 PM).Both samples were used to estimate protein- creatinine ratio and then a 24 hours urine protein estimation was done and compared. RESULTS: There was good positive correlation between spot urine Protein Creatinine ratio of both samples taken at two different times of the day and estimated 24 hours urinary protein though the best correlation was seen in early morning urine sample than evening sample(r=0.931 in 7AM &r=0.872 in 7 PM; p <0.01). The maximum correlation was seen in patients with normal/mild renal dysfunction and non nephrotic range proteinuria. The positive correlation was least in patients with moderate/severe renal dysfunction and nephrotic range proteinuria. CONCLUSION : Urine protein Creatinine ratio is easy to perform, inexpensive and less time consuming method for measuring of proteinuria. It can thus be used in the outpatient setting for screening and quantification of proteinuria.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Protein - Creatinine ratio ; Proteinuria ; urine analysis ; 24 hours urinary protein. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 16 Feb 2018 18:11 |
| Last Modified: | 16 Feb 2018 18:11 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5773 |
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