Meenakshisundaram, V (2009) Study on postprandial hypertriglyceridemia as an independent risk factor for ischemic heart disease. Masters thesis, Government Mohan Kumaramangalam Medical College, Salem.
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Abstract
INTRODUCTION : Coronary heart disease is the leading cause of death in Western countries and it is now an increasing problem in developing countries too, due to changes in life style and dietary habits. Heart Disease is responsible for more deaths and disability among Western Population, both male and female, than any other killer disease, and it is quickly establishing itself as the leading cause of death and disability among Indians as well. This sudden increase in incidence of Heart disease is seen in our people, as they have adopted a more sedentary westernized life style, together with the intake of high-fat, high-salt diet and processed foods that have come to be associated with technological affluence. Researchers are noticing that Diseases prevalent in western hemisphere are now becoming more and more the prevalent causes of death in Asia. AIMS AND OBJECTIVES : 1. To study relation between risk factors for atherosclerosis and fasting and postprandial triglyceride levels in patients of unstable angina. 2. To establish that post-prandial triglycerides level is a better indicator as a ‘risk factor’ for atherosclerosis. 3. To study risk factors for atherosclerosis in diabetic and nondiabetic patients having normal fasting triglyceride. MATERIALS AND METHODS MATERIALS: This study was carried out in reference to 100 patients, diagnosed to have ischemic heart disease who were admitted at Govt. Mohan Kumramangalam Medical College Hospital, Salem for unstable angina. The study was approved by the Department of medicine. This study was conducted on patients between January 2007 and June 2008. INCLUSION CRITERIA: 1. Unstable angina diagnosed on classical anginal chest pain or anginal chest pain equivalent With ECG showing ST segment depression in two consecutive chest leads or Limb leads and Normal S.CPK-MB levels. 2. Fasting S. Triglycerides <150 mg% 3. Fasting S. Cholesterol < 180 mg% EXCLUSION CRITERIA: 1. Patient on treatment with Tablet Rosiglitazone in past one month. 2. On treatment with lipid lowering drugs. 3. Suspected cases of Prinzmetal’s angina 4. Rheumatic heart disease 5. Oral contraceptive pills or other hormone therapy 6. Abnormal liver and Renal function test. METHODS: A complete and detailed history of patient with address, occupation, past history of diabetes, hypertension, family history, habits of smoking and alcohol was noted. CLINICAL ASSESSMENT : • A complete physical and cardiovascular system examination performed. • Blood pressure measurements were performed with mercury sphygmomanometer in a standardized fashion. • Height measured in standing position without shoes with a standard tape meter. • Body mass index was calculated with formula of B.M.I = wt(kg) /Ht (m2) SUMMARY : In the study entitled “Postprandial Hypertriglyceridemia as a Independent Risk Factor for Ischemic Heart Disease” conducted at Govt. Mohan Kumaramangalm Medical College Hospital, Salem from July 2007 to June 2008, a total of 100 patients of ischemic Heart disease were included as per defined criteria. Postprandial Hypertriglyceridemia was found in 64%, 52% had high BMI, 73% patients had High Waist Hip ratio and 64% patients had Diabetes Mellitus. Increased triglyceride level is a risk factor for cardiovascular disease independent of HDL cholesterol level. Our study showed patients of ischemic Heart disease have high postprandial triglyceride levels inspite of normal fasting triglyceride level. There is a positive correlation between high waist-hip ratio, diabetes mellitus and postprandial hypertriglyceridemia in ischemic heart disease patients. 63 Non fasting triglyceride levels indicate the presence of remnant lipoproteins, which may promote atherosclerosis. Postprandial Hypertriglyceridemia may be an independent risk factor for Atherosclerosis in Ischemic Heart Disease patients. Evaluation of postprandial triglyceride levels is important during assessment of ischemic heart disease patients. CONCLUSION : In our study with reference to patient of ischemic heart disease, postprandial Hypertriglyceridemia was found in 64% patients, having normal fasting triglyceride level. There is statistically a significant correlation between postprandial triglyceride and ischemic heart disease, even in patients having normal fasting triglyceride level. It means that patients having high postprandial triglyceride levels have higher risk of Ischemic heart disease. The relative risk is 1.44. There is statistically a significant correlation found between postprandial Hypertriglyceridemia and high waist-hip ratio and Diabetes Mellitus.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | postprandial hypertriglyceridemia ; independent risk factor ; ischemic heart disease. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 16 Feb 2018 17:01 |
| Last Modified: | 16 Feb 2018 17:01 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5768 |
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