Viju, Moses (2007) Enteral Nutritional supplementation in mechanically ventillated patients with organophosphorus poisoning: A randomized controlled trial. Masters thesis, Christian Medical College, Vellore.
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Abstract
AIM : To study the effect of early enteral nutritional supplementation in intubated patients with OP posioning admitted to the medical ICU of a tertiary care hospital. METHODS : Design of study: Randomized controlled trial, not blinded. Outcomes: The primary outcome was the frequency of hospital acquired infections. Secondary outcomes were mortality, duration on ventilator, length of stay and feeding related complications. RESULTS : The difference in total calories recieved was statistically significant. The primary and secondary outcomes were assessed in 59 patients. There were no differences in the rate of hospital acquired infections between the two groups. Stratification of patients according to average daily caloric intake also failed to demonstrate any benefit for the higher calorie group. Duration of stay in ICU and in hospital, and duration on ventilator showed insignificant trends towards better results for those patients not enterally fed. Tracheostomy was associated with prolonged hospital stay in both groups. Mortality was not affected by enteral feeding. Feeding related complications were less common than in other studies. Early enteral feeding was found to be safe in this population. CONCLUSION: In patients admitted with organophosphorus poisoning needing mechanical ventilation, early enteral nutritional supplementation is safe but is not associated with improvement in incidence of infectious complications or mortality. It may prolong the duration on ventilator and the length of stay.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Enteral Nutritional supplementation ; mechanically ventillated patients ; organophosphorus poisoning ; randomized controlled trial. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 15 Feb 2018 18:02 |
| Last Modified: | 15 Feb 2018 18:03 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5728 |
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