Rajiv, A (2006) Etiology and Clinicopathological Profile of Patients with Pancytopenia. Masters thesis, Christian Medical College, Vellore.
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Abstract
INTRODUCTION : Pancytopenia refers to reduction in all three formed elements of blooderythrocytes, leucocytes and platelets. It is not a disease entity, but rather a triad of findings[anemia, leucopenia, thrombocytopenia] that may result from number of disease processes. The pattern of diseases causing pancytopenia is expected to vary in different population groups with their differences in nutritional status and prevalence of infective disorders. In India causes of pancytopenia are not well defined. Clinical features are those due to pancytopenia perse, and those of causative disorder. The presenting symptoms are usually attributable to anaemia / thrombocytopenia. Leucopoenia is an uncommon cause of initial presentation, but can be the most serious threat to life during subsequent course of disorder. Major diagnostic problems occur when there are no specific features in blood to suggest the diagnosis, or when the clinical features are not specific to point to the cause of an associated feature such as splenomegaly or lymphadenopathy. The prognosis depends both on the severity of pancytopenia and on the nature of underlying condition. The most common etiology from studies in developed countries have been aplastic anaemia and malignant myeloid disease. A few Indian studies however report a high incidence of megaloblastic anaemia. This seems to reflect the higher prevalence of nutritional anaemia in Indian subjects. It is important to investigate the etiology so as to formulate a rational approach to diagnosis and management. AIMS AND OBJECTIVES : To study the etiology and clinicopathological profile of patients presenting with pancytopenia at Christian Medical College, Vellore during the study period. PATIENTS AND METHODS : Study Setting: The study was carried out in subjects attending the Christian Medical College Hospital, Vellore, a tertiary care teaching hospital. Study Design: Cross sectional survey of patients with pancytopenia. Subjects: Consecutive patients with a diagnosis of pancytopenia, defined as Hemoglobin < 10g/dl, and Total leucocyte count < 4000/cu.mm, and Platelet count < 1,00,000/cu.mm. Patients were recruited from inpatient as well as outpatient departments of General Medicine and Haematology. All newly detected cases of pancytopenia were taken up for further evaluation. Patients who had normal blood counts at first visit and subsequently had pancytopenia [secondary to drugs, radiotherapy. etc] were not included in the study. Inclusion criteria: All newly detected adult patients [age >12 years] with pancytopenia were included in the study. Exclusion criteria: 1. Patients with normal blood counts at first visit and subsequently manifesting Pancytopenia [secondary to drugs, radiotherapy. etc]. 2. Age <12 years. Subject enrollment: The list of patients fulfilling the inclusion criteria were obtained daily from the Department of clinical pathology [Hospital numbers, Name and Age] and then traced for further evaluation and diagnostic work up. OPD patients who could not be seen the same day were followed up during subsequent visits.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Etiology ; Clinicopathological Profile ; Patients ; Pancytopenia. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 15 Feb 2018 17:13 |
| Last Modified: | 15 Feb 2018 17:13 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5709 |
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