Kothai, G (2012) Diagnostic accuracy of corrected QT interval as surrogate Marker in Diabetes Mellitus Patients with Cardac Autonomic Neuropathy. Masters thesis, K.A.P. Viswanatham Government Medical College, Tiruchirappalli.
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Abstract
OBJECTIVES : To study the prevalence and risk factors for cardiac autonomic neuropathy (CAN) and the utility of prolongation of corrected QT interval (QTc) in the ECG to diagnose CAN in patients with diabetes mellitus. DESIGN AND SETTING : Cross-sectional study conducted among 100 patients attending the diabetic clinic of K.A.P.V. Govt. Medical College, Trichy. METHODS : The prevalence of CAN among 100 patients with type 2 diabetes mellitus was assessed by the five autonomic function tests by Ewing’s methodology. The CAN score in each patient and its relationship to the QTc interval were analysed. Possible influences of duration of diabetes and heart rate variability on the occurrence of CAN also were studied. RESULTS : The prevalence of CAN was 58 %.Significant risks for CAN among patients with type 2 diabetes were prolonged QTc , reduced heart rate variability and disease duration over 10 years. Disease duration over 10 years resulted in QTc prolongation in a significant numbers of cases with type 2 diabetes. The sensitivity, specificity and positive predictive value of QTc prolongation for the diagnosis of CAN were77%, 81% and 93.85% respectively. Higher CAN scores correlated with longer QTc intervals (p<0.001). CONCLUSIONS : The prevalence of CAN in diabetes mellitus is high. Longer duration of diabetes is a significant risk factor. QTc interval in the ECG can be used to diagnose CAN with reasonable sensitivity, specificity and positive predictive value.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Diagnostic accuracy ; corrected QT interval ; surrogate Marker ; Diabetes Mellitus Patients ; Cardac Autonomic Neuropathy. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 13 Feb 2018 16:19 |
| Last Modified: | 13 Feb 2018 16:19 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5691 |
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