A Study of Lipid Profile in Chronic Kidney Disease patients

Ganesan, K (2012) A Study of Lipid Profile in Chronic Kidney Disease patients. Masters thesis, K.A.P. Viswanatham Government Medical College, Tiruchirappalli.

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Abstract

INTRODUCTION : Cardiovascular disease (CVD) is a major cause of mortality in patients with mild to moderate chronic kidney disease (CKD) and endstage renal disease (ESRD). Cardiovascular mortality 500 times higher in 25- to 34-year-old ESRD patients than in individuals from the general population of the same age and race. Primary care physicians (PCP) often manage patients with CKD in the early stages of the disease and have a pivotal role in affecting longterm outcomes in CKD patients related to cardiovascular and all-cause mortality. In a retrospective cohort study only a tiny minority of patients (0.5–1%) with mild to moderate CKD developed ESRD over a 5-year followup, while as many as 19 and 24% of these patients with mild and moderate renal insufficiency, respectively, died mostly of cardiovascular complications in the same period. Hyperlipidemia, one of the important risk factor of atherosclerosis, is an abnormality commonly encountered in patients with chronic kidney disease. AIMS and OBJECTIVES : 1. To identify lipid pattern in chronic kidney disease patients. 2. To analyze lipid alterations that can occur in Chronic Kidney Disease patients. 3. To study the correlation between renal function and lipid abnormalities in Chronic Kidney Disease. MATERIALS AND METHODS : This study was conducted in 50 patients with chronic kidney disease and 50 normal people taken as controls. All the patients in this study group were selected from those who were admitted to department of Internal Medicine, Govt. Annal Gandhi Memorial Govt. Hospital, attached to K.A.P.Viswanatham Govt. Medical College, Trichy. Inclusion Criteria : 1. Patients between age group of 40 to 80 years with established chronic Kidney disease. 2. Patients who were on conservative treatment. 3. Established renal failure was ensured by radiological evidence. Exclusion Criteria : 1. Patients with Acute renal failure, nephrotic syndrome. 2. Who are on drugs β blockers, statins and oral contraceptive pills. 3. Pregnant female patients. CONCLUSION : 1. HDL-C levels were lower and triglycerides, total cholesterol and TGL levels were higher in the study group compared to controls. 2. There is a statistically significant increase in serum triglycerides level in patients with CKD stage 3, 4 and 5. 4. Predominant lipid abnormalities were reduced HDL-C levels and elevated TGL. 5. There was a negative correlation exists between serum HDL-C level and GFR levels which was statistically significant. 6.. Significant number of patients showing ECG changes of left ventricular hypertrophy 34 %and ischemic changes 32%.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Lipid Profile ; Chronic Kidney Disease patients.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 13 Feb 2018 16:14
Last Modified: 13 Feb 2018 16:14
URI: http://repository-tnmgrmu.ac.in/id/eprint/5690

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