Chennuru, Phaneendra Kumar (2014) Formulation and Evaluation of Cefixime Floating Matrix Tablets. Masters thesis, Cherraan's College of Pharmacy, Coimbatore.
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Abstract
The present research work Cefixime Controlled Gas Powered System (CGPS) are retained for longer period oftime in the stomach. The bioavailability of cefixime is around 40-50 %. The gas powered tablets of Cefixime were prepared by direct compression method. The formulations were evaluated for quality control tests and all the physical parameters evaluated are within the acceptable limits. Drug compatibility with excipients was Checkedby FTIR studies and these results were revealed that, no interaction between drug with the excipients used. The results of in-vitro buoyancy time and lag time study revealed that as the concentration of sodium bicarbonate increases there is increase in total buoyancy time and decrease in lag time. In all the formulations buoyancy time ranges from 40-690 min and lag time ranges from 65-10 min. The formulation F3 shows the lag time of 10 min. and buoyancy time 600 min. The release of cefixime from all the formulations was in the range of 46.67- 58.93 % at the end of 6 hrs. and 64.43-98.49 % at the end of 24 hrs. The CGPS system using sodium carboxy methyl cellulose along with sodium bicarbonate and citric acid added significantly increased the drug release from the formulation. It is also evident that sodium bicarbonate levels had a considerable effect on the drug release profile. The stability study conducted as per the ICH guidelines and the formulations were found to be stable. From this study, it can be concluded that, the formulation retained for longer periods of time in the stomach and provides controlled release of the drug. Hence, improve the therapeutic effect of the drug.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Cefixime ; Lactose ; Hpmc ; Carbopol ; Eudragit ; Sodium bicarbonate; Citric acid, Mg.sterate, Talc. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 06 Feb 2018 10:45 |
| Last Modified: | 06 Feb 2018 10:45 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5643 |
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