Sharmila, B (2014) A Study on the correlation between sputum smear status and CD4 count in cases of Pulmonary Tuberculosis with HIV coinfection. Masters thesis, Tirunelveli Medical College, Tirunelveli.
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Abstract
BACKGROUND OF THE STUDY : Around 2.5 million people are infected with HIV in India. Estimated 40% of the Indian population is infected with M.tuberculosis. Estimated 1 million persons are co-infected with M.tuberculosis and HIV. Risk of developing TB is higher in HIV infected persons. Life time risk of developing TB is 60% in persons infected with both HIV and TB. Surveys in India show 1 to 13% prevalence of HIV among TB patients. Hence the need of more studies in HIV TB coinfection is warranted. WHO states that sputum positivity decreases as CD4 count decreases. But this expectation has not been substantiated in a few studies done in the past. Hence this study was undertaken to find the correlation between sputum smear status and CD4 count in cases of pulmonary tuberculosis with HIV coinfection in Tirunelveli medical college hospital ,being a tertiary care referral center. METHODOLOGY : In our hospital based cross sectional study,50 patients with HIV infection who developed pulmonary tuberculosis were tested for sputum acid fast smear status and correlated with CD4 count and radiologic findings. RESULTS : Sputum smear negative cases were more prevalent in patients CD4 count less than 200 whereas sputum smear positive cases were common with CD4 count more than 200 with a statistically significant difference (p=0.0001) which endorses the fact by WHO that sputum smear negativity increases with increase in the degree of immunosuppression. CONCLUSION : Though sputum smear microscopy remains a gold standard method for diagnosing pulmonary tuberculosis in immune compromised host with CD4 count more than 200, there is an urgent need for better diagnostic tools in patients with CD4 count below 200.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | HIV TB coinfection, WHO, CD4 count. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 05 Feb 2018 02:11 |
| Last Modified: | 05 Feb 2018 02:11 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5620 |
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