Subbiah, - (2014) Formulation and Evaluation of Amoxicillin & Potassium Clavulanate Dispersible Tablet. Masters thesis, C. L. Baid Metha College of Pharmacy, Chennai.
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Abstract
AIM AND OBJECTIVE OF THE STUDY:The aim of the research work is to formulate and evaluate of Amoxicillin and potassium clavulanate dispersible tablet. The oral route is the most frequently used route for drug administration. Oral dosage forms are usually for systemic effects resulting from drug absorption through the various mucosa of the gastrointestinal tract. The parenteral route of administration is an important in mandatory condition; otherwise it is probable that at least 90% of all drugs used to produce systemic effects are administered by the oral route. The drugs that are administered orally, solid dosage forms represent the preferred class of product. The reasons for this preference are as follows:Tablets and capsules represent unit dosage forms in which one unit dose of the drug has been accurately placed, whereas in liquid oral dosage forms measurements are typically in error when the drug is administered by the patient. Liquid oral dosage forms are much more expensive to ship and breakage or leakage during shipment is a more serious problem than with solid oral dosage forms. Liquids are less portable and require much more space. Drugs are in general less stable in liquid form than in a dry state and expiration dates tend to be shorter. Compared with other routes, the advantages of the oral solid dosage forms are as follows: Simplest, Most compliance, Safety. The disadvantages include relatively slow onset of action as compared to parenterals, difficult to swallow for kids, terminally ill and geriatric patients and destruction of certain drugs by the enzymes and the secretion of the GIT. e.g.: Insulin.The most popular oral dosage forms are tablets, capsules, suspensions, solutions, emulsions. The other dosage forms that are administered orally are powders, granules, syrups and elixirs. Based on the above advantages, the selected antibiotic drug is developed as tablets for oral administration. Fast Dissolving Drug Delivery System emerged from the desire to provide patient with conventional mean of taking their medication. Difficulty in swallowing is a common problem of all age groups, especially elderly and paediatrics, because of physiological changes associated with these groups of patients other categories that experience problems using conventional oral dosage forms includes are the mentally ill, uncooperative and nauseated patients, those with conditions of motion sickness, sudden episodes of allergic attack or coughing. Sometimes it may be difficult to swallow conventional products due to unavailability of water. These problems led to the development of novel type of solid oral dosage form called “dispersible Tablets”. This tablet disintegrates instantaneously when placed on tongue, releasing the drug that dissolves or disperses in the saliva. The growing importance of mouth dissolving tablet was underlined recently when European Pharmacopoeia adopted the term “Oro dispersible Tablet” as a tablet that to be placed in the mouth where it disperses rapidly before swallowing. The main criteria for mouth disintegrating (dissolving) tablet is to disintegrate or dissolve rapidly in oral cavity with saliva in 15 to 60 seconds, without need of water and should have pleasant mouth feel . Mouth dissolving tablets are also known as fast dissolving tablet; melt in mouth tablet, rapiment, and porous tablet, dispersible tablet. The uses of amoxicillin and clavulanic acid dispersible tablet are used to treat certain infections caused by bacteria including infections of the ears, lungs, sinus, skin, and urinary tract.The aim of the study is to formulate and evaluate of Amoxicillin And Potassium Clavulanate dispersible tablets.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Amoxicillin ; Potassium Clavulanate Dispersible Tablet |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 02 Feb 2018 11:56 |
| Last Modified: | 02 Feb 2018 11:56 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5608 |
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