Soma Sekhar, Goud (2009) Identification of Helicobacter pylori in Saliva of patients with and without Gastritis by polymerase chain reaction. Masters thesis, Ragas Dental College and Hospital, Chennai.
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Abstract
1. 30 subjects were enrolled for the study. 2. 20 cases were symptomatic gastritis, of whom 10 had biopsy proven H.pylori infection. 3. In group 2, all were asymptomatic at the time of study (n =10) (four had previous history of gastritis treated). 4. The mean age of male patients in group1 was 39.43 ± 10.01 and female patients was 52.33 ±.19.83. 5. The mean age of male subjects enrolled in group 2 was 27.75 ± 2.06 and female patients was 27.83 ± 4.54 6. When biopsy was taken as gold standard, PCR of saliva showed sensitivity of 80%, specificity 70%, positive predictive value 72.2% and negative predictive value 77.7% respectively. 7. When clinical gastritis was used as standard for comparison with PCR of saliva, the sensitivity was 58%, specificity was 50%, positive predictive value was 82.35 % and negative predictive value was 23% respectively. In conclusion, the results of our study indicate that PCR analysis of saliva is useful for identification of H. Pylori. Saliva could serve as an effective, valuable, noninvasive specimen to diagnose / monitor the prognosis of H. Pylori infection in comparison to existing diagnostic modalities. However, the exact sensitivity and specificity of saliva based PCR to diagnose H. pylori needs to be demonstrated in further studies involving larger samples.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Helicobacter pylori, Saliva of patients, with and without Gastritis, polymerase chain reaction. |
| Subjects: | DENTAL > Oral Pathology and Microbiology |
| Depositing User: | Kambaraman B |
| Date Deposited: | 24 Jan 2018 03:53 |
| Last Modified: | 24 Jan 2018 03:53 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5538 |
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