Devi, M (2006) Evaluation of T cells & Langerhans Cells in Lichen Planus & Lichenoid Mucositis: Immunohistochemical study. Masters thesis, Ragas Dental College and Hospital, Chennai.
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Abstract
A total of 40 patients were included in our study, comprising of 15 patients of LP, 15 LM and 10 NM. • In our study, the mean age of LP was 36(± 17) years for males and 44(± 12) years for females, whereas LM was 38(± 17) years for males and 40(± 11) years for females. Both LP & LM showed a female predominance. • Buccal mucosa was the affected site in all cases of LP, however 60% cases of LM also showed the same site of occurrence. 80% LP showed bilateral distribution whereas 93% of LM had unilateral distribution. • Immunohistochemical study was done to evaluate the number and expression of LC, and to demonstrate the expression of T cells in LP, LM & NM. • Increased number of LC was observed in LP, in the basal and supra basal layer of epithelium and in the connective tissue compared to LM and NM by using CD1a staining. • Increased intensity of expression of LC was observed in LP, in basal and supra basal layer of epithelium compared to LM, NM and this was not statistically significant. • Increased CD1a expression was observed in the connective tissue in the sequence of LP> LM > NM and this was statistically significant. • Increased CD45RO expression was observed in the connective tissue in the sequence of LP> LM > NM and this difference in staining intensity was statistically significant. • The present study clearly demonstrates a statistically significant increase in number and expression of LC and also an increase in the expression of memory T cell in LP than in LM, indicating the possible different immunopathogenic mechanisms.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | T cells, Langerhans Cells, Lichen Planus, Lichenoid Mucositis, Immunohistochemical study. |
| Subjects: | DENTAL > Oral Pathology and Microbiology |
| Depositing User: | Kambaraman B |
| Date Deposited: | 24 Jan 2018 03:53 |
| Last Modified: | 24 Jan 2018 03:53 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5534 |
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