Chakshu, Aggarwal (2010) The concordance of minor salivary gland histology with the clinical parameters in patients with a provisional diagnosis of Sjogren's syndrome. Masters thesis, Tamil Nadu Government Dental College and Hospital, Chennai.
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Abstract
OBJECTIVE : The objective of this prospective study was to evaluate the minor salivary gland histology of patients with a provisional diagnosis of Sjogren’s syndrome in relation to clinical parameters to determine the level of correlation in patients with and without Sjogren’s syndrome. MATERIAL AND METHODS : A total of 71 cases with provisional diagnosis of Sjogren’s syndrome were studied who reported between Jan 2009 till July 2009 in the Department of Oral and Maxillofacial Pathology, Tamil Nadu Government Dental College and Hospital, Chennai, India for the histopathological evaluation of minor salivary gland lobules. RESULTS : About 25% cases having provisional Sjogren syndrome were diagnosed as definite Sjogren’s syndrome positive. Sjogren’s syndrome affected older age group and showed characteristic female predilection compared to non-Sjogren’s cases. Clinical features of xerostomia and keratoconjuctivitis sicca were seen in both Sjogren’s syndrome positive and negative cases with more expression in Sjogren’s syndrome cases. Both showed degenerative changes on histopathological evaluation of minor salivary glands but a better correlation was found between clinical and histological features in non Sjogren’s cases when compared to Sjogren’s syndrome cases. CONCLUSION : Correlation was found between histological and clinical features in Sjogren’s syndrome, but it was not consistently present in all the cases. Hence diagnosis of Sjogren’s syndrome should be rendered carefully after observing clinical features and histological features.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Sjogren’s syndrome, Xerostomia, Keratoconjunctivitis sicca, Pathology, Histology, Chennai, Tamil Nadu. |
| Subjects: | DENTAL > Oral Pathology and Microbiology |
| Depositing User: | Kambaraman B |
| Date Deposited: | 24 Jan 2018 03:53 |
| Last Modified: | 24 Jan 2018 03:53 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5533 |
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