Suresh, G (2015) A study on correlation of various anthropometric measures and serum homocysteine level with the severity of coronary artery disease in young patients undergoing coronary angiography. Masters thesis, Stanley Medical College, Chennai.
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Abstract
METHODOLOGY Patients admitted for angiography between November 2013 to September 2014 will be included in the study. DATA COLLECTED USING A PROFOMA MEETING THE OBJECTIVES OF THE STUDY. DETAILED HISTORY, PHYSICAL EXAMINATION AND NECESSARY INVESTIGATIONS WILL BE UNDERTAKEN. They are subjected for anthropometry measurements including height, weight, BMI, hip and waist circumference, WHR, sagittal abdominal diameter, triceps skin fold thickness and SAD/TSFT ratio measured. Also their serum homocysteine level, glycemic status, Presence or absence of hypertension and diabetes, smoking and alcohol intake with duration, life style & physical activity, frequency of chest pain, ECG findings and echo status will be noted prior to angiogram. Post angiogram evaluation of severity of coronary artery stenosis made my Modified Gensini Score. THE PURPOSE OF THE STUDY WILL BE EXPLAINED TO THE PATIENT AND INFORMED CONSENT OBTAINED CONCLUSION In my study using 75 patients under 50 years, I am able to come to a conclusion of some anthropometric variables better correlating with the severity of coronary stenosis and some not showing much correlation as listed below 1) Increased Waist-hip ratio, sagittal abdominal diameter, triceps skin fold thickness and SAD/TSFT ratio has got better correlation with the severity of coronary artery disease, with SAD/TSFT and WHR has got maximum significance of all anthropometric measurements. 2) Increased BMI poorly correlating with the severity of CAD as shown by p value more than 0.05. 3) Increased homocysteine level better correlates with the severity of coronary artery disease. 4) Increased LDL cholesterol value had good correlation with CAD severity butdecreased HDL cholesterol not correlating much with coronaryartery disease. 5) Duration of smoking but not mere smoking history better correlates with the severity of coronaryartery disease.Smoking is found to be an independent high risk factor even in patients with low BMI, low waist or hip circumference and low WHR or SAD/TSFT ratio. 6) Presence of hypertension and duration of diabetes got positive correlation on coronary artery disease severity. 7) Left ventricular ejection fraction (LVEF) also correlates with the severity of coronary artery disease with an inverse relation between them. 8) Modified gensini score – higher the modified gensini score, severe is the coronary artery disease. 9) It appears that the old concept of BMI being considered as major risk factor in the past will not apply nowadays as an important determinant for CAD risk assessment, as it is shown in our study and in many major studies to be statistically less significant and it’s better to give importance to central Vs peripheral obesity ratio methods to assess future risk of CAD. 10) We feel great emphasis should be given on cessation of smoking compared to control of obesity as it’s a major atherosclerotic risk factor even in thin individuals and those patients are prone for CAD at very young age.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Anthropometry; Sagittal Abdominal Diameter; Triceps Skin Fold Thickness; Serum Homocysteine; Modified Gensini Scoring; Coronary Angiography |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Punitha K |
| Date Deposited: | 17 Jan 2018 09:22 |
| Last Modified: | 17 Jan 2018 09:22 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5476 |
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