Dheepak Selvaraj, A (2015) Is severe Vitamin D Deficiency an independent risk factor for Critical Limb Ischemia (CLI) in patients with Peripheral Arterial Occlusive Disease (PAOD)? Masters thesis, Christian Medical College, Vellore.
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Abstract
HYPOTHESIS : Vitamin D is not a risk factor in peripheral arterial occlusive disease BACKGROUND : The role Vitamin D in metabolic homeostasis is well understood as it is required to maintain normal levels of calcium and phosphates. The Vitamin D receptors (VDR) are also present in the heart and blood vessels. In animal studies, absence of vitamin D receptors causes cardiovascular disease. Critical limb ischemia is a severe form of peripheral arterial occlusive disease (PAOD) which includes rest pain, tissue loss in the form of ulcer and gangrene. Medical therapy and surgical revascularization are the best options of treatment for limb salvage. METHODS : This was an observational crossectional study. Patients with atherosclerotic PAOD were classified into claudicants and critical limbs. Their serum Vitamin D levels were checked after informed consent. The results were analyzed using inferential statistics. RESULTS : There were 50 claudicants and 50 patients with critical limb ischemia. 80% were men and 20% were women. There was statistically significant difference of severe vitamin D deficiency in the critical limbs compared to the claudicants (32.7%, 14% (p =0.004). Low ankle brachial index (<0.4) was related with severe vitamin D deficiency. CONCLUSIONS : Severe vitamin D deficiency is an independent risk factor in critical limb ischemia.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Vitamin D Deficiency, risk factor, Critical Limb Ischemia (CLI), Peripheral Arterial Occlusive Disease (PAOD). |
| Subjects: | MEDICAL > Vascular Surgery |
| Depositing User: | Kambaraman B |
| Date Deposited: | 08 Jan 2018 18:12 |
| Last Modified: | 08 Jan 2018 18:12 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5409 |
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