Prevalence of Diabetes Mellitus, Obesity and Metabolic Syndrome in Indian Patients with Cryptogenic Cirrhosis

Bharath Kumar, C (2015) Prevalence of Diabetes Mellitus, Obesity and Metabolic Syndrome in Indian Patients with Cryptogenic Cirrhosis. Masters thesis, Christian Medical College, Vellore.

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Abstract

AIM OF THE STUDY : To study the prevalence of diabetes mellitus, obesity and metabolic syndrome in cryptogenic cirrhosis . METHODS AND MATERIALS : During August 2013 to December 2014 all cases (cryptogenic cirrhosis) and controls (hepatitis B/C related cirrhosis) above 40 years of age were consecutively and prospectively recruited. After informed consent, cases and controls underwent a detailed clinical and laboratory evaluation to assess the cause and severity of liver disease and prevalence of DM, obesity and metabolic syndrome. . Continuous variables were expressed as means ± standard deviation and categorical variables were expressed as numbers and percentages. Differences between the categorical parameters were tested by χ2 tests. Independent t-tests were conducted for differences between groups for continuous variables. RESULTS: 118 cases (M-74 % ; age 55 ± 8.6 years mean±SD; Childs class A/B/C-46/38/16) and 59 Controls (M- 80% ;age 54 ± 8 years mean±SD; Childs class A/B/C-56/30/14) were enrolled. 54 % cases were obese compared to 39 % controls (p-0.089).DM was more prevalent in cases as compared to controls{ 52 % v/s 27 % (p-0.002)}. 30% cases and 13 % controls had a family history of DM(0.016) and 21% cases and 3.5 % controls had family history of obesity(p0.002). Metabolic syndrome was noted in 65% of cases compared to 44 % of controls (p-0.01). CONCLUSION : Higher prevalence of risk factors for NAFLD underlies the important contribution of NAFLD in Indian patients with cryptogenic cirrhosis.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Cryptogenic cirrhosis, diabetes mellitus(DM), metabolic syndrome(MS), obesity.
Subjects: MEDICAL > Gastroenterology
Depositing User: Kambaraman B
Date Deposited: 08 Jan 2018 16:46
Last Modified: 08 Jan 2018 16:49
URI: http://repository-tnmgrmu.ac.in/id/eprint/5399

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