Shanmugapriya, S (2017) Formulation and Evaluation of Polyherbal Haematinic Capsules. Masters thesis, Madras Medical College, Chennai.
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Abstract
AIM AND OBJECTIVE:The aim of the present work is to develop a polyherbal haematinic capsules from the selected plant materials and evaluate the same. The objectives are selection of the plant material followed by, To perform the various phytochemical studies,Evaluation of anti-anaemic activity of the extracts, Formulation of polyherbal haematinic capsules, Evaluation of the formulated capsules.SUMMARY AND CONCLUSION:There are several synthetic drugs available and are still on the way being discovered by many young research fellows of our kind, but still the affinity for herbal drugs hasn’t reduced. People feel secure in using the plant based drugs for their chronic diseases. People still rely on nature which has blessed human kind with abundant medicinal plants for prevention and cure of disease. The prevalence of anaemia is increasing worldwide. Though medicines are available for the treatment of anaemia in allopathic system of medicine, its compliance is an issue due to sideeffects. Therefore this study is an attempt to formulate and evaluate the folklore claims of six indigenous herbs viz., Boerhavia diffusa, Eclipta prostrata, Moringa oleifera, Murraya koenigii,Phyllanthus embelica, Tinospora sinensis,as capsules for the treatment of anaemia. The selected plant powders were subjected to preliminary evaluation. The physio-chemical constants like ash values, extractive values, loss on drying, were performed. The results obtained proved the procured raw materials were of good standard. Phytochemical analysis was performed for the powder as well as the ethanolic extracts of the plants. It showed the presence of major phyto constituents like alkaloids, flavanoids, terpenoids, steroids ,carbohydrates, proteins. Chromatograhical studies revealed the various Rf values, which ensures the presence of the various phytoconstituents. The dried extracts were transformed to powder, and subjected to pre-formulation studies and it proved the powder had good flow characterstics. Hence it was filled in capsules and evaluated for the parameters like,appearance, uniformity in weight, disintergration time. The results were good. The in-vivo Anti-anaemic activity was carried out by phenyl hydrazine induced anaemic model using the polyherbal extract. Two doses of the polyherbal extract i.e 200mg/kg and 400mg/kg orally were used for anti-anaemic evaluation. The studies indicates that polyherbal extract at the dose of 400mg/kg has better anti-anaemic activity. The haematological studies also showed increase in RBC and haemoglobin content and the overall improvement in blood quality. These changes are markedly good at higher testdose. Hence, from these studies it is concluded that the formulation proves effective in the treatment of anemia and therefore is haematinic in nature! The future studies are recommemded in the stability determination areas for the formulated polyherbal capsules. It also includes the clinical trials,to prove the haematinic activity of the capsules in human subjects.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Polyherbal Haematinic Capsules |
| Subjects: | PHARMACY > Pharmacognosy |
| Depositing User: | Ravindran C |
| Date Deposited: | 08 Jan 2018 05:35 |
| Last Modified: | 08 Jan 2018 05:35 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5375 |
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