Deepanchakkaravarthi, S (2017) Evaluation of Anti-Anxiety and Sedative Effects of Various Extracts of Amomum Subulatum Seeds in Swiss Albino Mice. Masters thesis, Madras Medical College, Chennai.
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Abstract
AIM: The aim of the present study is to evaluate the anti-anxiety and sedative effects of various extracts of Amomum subulatum seeds in Swiss albino mice. OBJECTIVE: To analyse the phytochemical profile of various extracts of Amomum subulatum seeds. In-vitro antioxidant activity is used to determine the presence of active constituents in various extracts. In-vivo spontaneous locomotor activity is to be done by actophotometer& open field for sedative activity. In-vivo antianxiety activity is to be done by elevated plus maze method.CONCLUSION:Preliminary phytochemical investigation was done for the various extracts of Amomum subulatum seeds. It was found to contain flavonoids, phytosterol, carbohydrate, terpenoids and Protein& amino acids, etc… The present study shows that the methanol and petroleum ether extracts of Amomum subulatum seeds have higher antioxidant activity which was determined using the method (Nitric oxide radical scavenging activity). The study shows that extracts of Amomum subulatum seeds at the dose of 200mg/kg has significant antianxiety and sedative activity. The study also shows that the antianxiety and sedative activity of various extracts of Amomum subulatum seeds at the dose of 200mg/kg is less efficacious when compared to the standard drug diazepam at the dose of 3mg/kg. The results from the experiments confirmed that the methanolic and petroleum ether extract from Amomum subulatum seeds posses a strong sedative and anxiolytic potential. However, the further studies in other models and extensive phytochemical analysis are necessary to identify the exact chemical compound and its possible mechanism of action underlying the anxiolytic and sedative effect of Amomum subulatum seeds.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Anti-Anxiety ; Sedative Effects ; Various Extracts ; Amomum Subulatum Seeds ; Swiss Albino Mice |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 08 Jan 2018 05:59 |
| Last Modified: | 08 Jan 2018 05:59 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5366 |
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