Balachandar, C (2017) Evaluation of in Vivo Hepatoprotective Activity of Erythrina Indica L., Stem Bark Extracts Against Carbon Tetrachloride Induced Hepatotoxicity in Wistar Albino Rats. Masters thesis, Madras Medical College, Chennai.
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Abstract
AIM AND OBJECTIVE:The literature review indicated that plant of Erythrina indica generally rich sources of antioxidants and hence may be considered to be good potential for hepatoprotective activity. From the literature review it is clear that no scientific work has so far been carried out on the stem bark of Erythrina indica Lam for hepatoprotective activity. The aim and objective of the study is Evaluation of the phytochemical screening of various extracts of stem bark of Erythrina indica Lam. Evaluation of the hepatoprotective activity of various extracts of stem bark of Erythrina indica in Carbon tetrachloride induced hepatotoxicity in rats. Biochemical estimations are, Estimation of Aspartate amino transferase (AST) Estimation of Alanine aminotransferase (ALT) Estimation of Alkaline phosphate (ALP) Estimation of Total bilirubin (TB) Estimation of Total protein content (TP) Estimation of serum Albumin (ALB) Assessment of in vivo antioxidant property of various extracts of stem bark of Erythrina indica Lam. Super oxide dismutase (SOD) Lipid peroxidation (LP) Glutathione peroxidase (GPx) Catalase (CAT) 8. CONCLUSION: The different extracts of the stem bark of Erythrina indica Lam possessed promising hepatoprotective activity against CCl4 induced hepatic damage. The hepatoprotective activity of Erythrina indica is found out to be more in ethanolic extract. The activity could be due to the improvement in the antioxidant enzyme level and a decrease in free radical levels. The presence of phytochemicals such as flavonoids has been shown to be responsible for hepatoprotective activity. Further studies can be carried out in the future to elucidate the mechanism of action of the ethanolic extract of stem bark of Erythrina indica Lam, which may then be followed and clinical studies to establish its efficacy in humans.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Vivo Hepatoprotective Activity ; Erythrina Indica L.; Stem Bark Extracts ; Carbon Tetrachloride Induced Hepatotoxicity in Wistar Albino Rats |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 08 Jan 2018 05:59 |
| Last Modified: | 08 Jan 2018 05:59 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5365 |
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