Neethi Shaju, - (2017) Neuroprotective Effect of Pterocarpus Marsupium Marketed Capsules against Vincristine Induced Neuropathy in Rats. Masters thesis, PSG College of Pharmacy, Coimbatore.
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Abstract
AIM: To evaluate the neuroprotective effect of Pterocarpus marsupium marketed capsules against vincristine induced neuropathy in rat model. OBJECTIVE: To study the effect of P.marsupium on behavioural models for neuropathic pain. To study the effect of P.marsupium on excitatory neurotransmitters (glutamate and aspartate) in vincristine induced rats. To study the effect of P.marsupium on histopathology of sciatic nerve. SUMMARY AND CONCLUSION: In our present study, we evaluated the anti-nociceptive effect of Pterocarpus marsupium marketed capsules (100mg/kg & 200mg/kg) post and co–administration against vincristine induced neuropathy in rat model. Pterocarpus marsupium capsules (100mg/kg & 200mg/kg) post and co–administration showed significant increase in pain threshold in thermal hyperalgesia (hot plate test), mechanical hyperalgesia (Randall Sellito test), mechanical allodynia (electronic Von Frey test). Neuropathic pain was induced by vincristine (75μg/kg) and the pain threshold was assessed by various behavioral studies. Vincristine caused a rise in the level of excitatory neurotransmitters such as glutamate and aspartate. PM exhibited both central and peripheral actions in nociception as it decreased the paw licking and elevation in both acute and delayed phase of formalin test. It attenuated the sciatic functional loss caused by vincristine. PM decreased the levels of excitatory neurotransmitters such as glutamate and aspartate in the brain. Histopathology of sciatic nerve also supported the neuroprotective activity of the drug as it caused axonal regeneration and reversed the histopathological changes caused by vincristine.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Neuroprotective ; Pterocarpus Marsupium Marketed Capsules ; Vincristine Induced Neuropathy ; Rats |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 08 Jan 2018 06:01 |
| Last Modified: | 08 Jan 2018 06:01 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5361 |
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