Neethu, Devasia (2017) Anti-Inflammatory, Antipyretic and Antibacterial Study of Kabasura Kudineer Choornam. Masters thesis, KMCH College of Pharmacy, Coimbatore.
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Abstract
AIM: Kabasura kudineer choornam, is a siddha formulation. It is commonly used for the treatment of fever with or without respiratory infection. The aim of current study is to assess the anti-inflammatory, antipyretic and antibacterial effect of aqueous extract of Kabasura kudineer choornam (AEKKC). OBJECTIVE: The objectives of the present study include: Evaluation of in vitro antioxidant activity of AEKKC Acute toxicity study of AEKKC Evaluation of anti-inflammatory, antipyretic and antibacterial activity of AEKKC CONCLUSION:The present study supports that aqueous extract of KABASURA KUDINEER CHOORNAM (AEKKC) have significant anti-inflammatory, antipyretic and antibacterial activity. On the basis of the study the formulation showed significant in vitro anti-oxidant activity by terminating the actions of free radicals. The AEKKC (200 mg/kg and 400 mg/kg) was studied for its anti-inflammatory activity using carrageenan and histamine induced inflammation. Diclofenac (20 mg/kg) was used as standard for both the models. The anti-pyretic activity was evaluated by Brewer’s yeast induced pyrexia model in which paracetamol (150 mg/kg) was used as standard. Thus the study proved that the AEKKC possesses significant (P<0.05) anti-inflammatory activity which was evident with reduction in mean paw edema volume in both carrageenan and histamine induced inflammatory models. In antipyretic activity, AEKKC demonstrated significant (P<0.05) protection by reducing yeast evoked elevated body temperature which is comparable to standard drug. Antibacterial activity was evaluated via disk diffusion method. The potential activity of extract may be due to the presence of phenols, flavonoids and other phytochemical constituents present in it. Thus from the above results it was concluded that the AEKKC showed anti-oxidant activity and promising anti-inflammatory, antipyretic and antibacterial activity.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Anti-Inflammatory ; Antipyretic ; Antibacterial Study ; Kabasura Kudineer Choornam. |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 08 Jan 2018 06:01 |
| Last Modified: | 13 Feb 2018 06:07 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5357 |
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