Evaluation of Neuroprotective Effect of Barleria Prionitis Linn in Animal Models of Parkinson’s Disease

Boopathi, T (2017) Evaluation of Neuroprotective Effect of Barleria Prionitis Linn in Animal Models of Parkinson’s Disease. Masters thesis, KMCH College of Pharmacy, Coimbatore.

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Abstract

The present investigation has been undertaken as study the anti-parkinson activity of aqueous extract of Barleria prionitis. The plant Barleria prionitis of family acanthaceae an ayurvedic herb which is known for its significant medical properties. Experiments were conducted following standard procedures. The aqueous extract of Barleria prionitis were evaluated for their invivo antioxidant and anti-parkison properties and neurotransmitters level. The anti-parkinson activity of AEBP was evaluated using MPTP induced parkinson and Rotenone induced Parkinson models. Levodopa was used as standard for both models. Extracts treated groups showed higher invivo antioxidant and anti-parkinson activities. They also showed higher activity in neurotransmitters level. AEBP exhibited similar anti-parkinson activity that of standard but with lesser magnitude. The result may be attributed to the chemical constituents such as iridoid glycosides present in it which may be due to their individual or cumulative effect that enhanced anti-parkinson activity and provided scientific evidence of the ethnomedicinal futures of Barleria prionitis. These findings could justify the inclusion of this plant in the management of parkinson’s disease.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Neuroprotective Effect ; Barleria Prionitis Linn ; Animal Models ; Parkinson’s Disease; AEBP; anti-parkinson ; MPTP ; rotenone ; chemical constituents
Subjects: PHARMACY > Pharmacology
Depositing User: Ravindran C
Date Deposited: 08 Jan 2018 06:01
Last Modified: 08 Jan 2018 06:01
URI: http://repository-tnmgrmu.ac.in/id/eprint/5356

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